{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:06:25Z","timestamp":1773453985793,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/02203\u20107"],"award-info":[{"award-number":["2017\/02203\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candidemia is a major cause of bloodstream infection in tertiary hospitals worldwide and fungal biomarkers may provide early diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the performance of (1\u20103)\u2010\u03b2\u2010D\u2010glucan (BDG) in the diagnosis of candidemia and its ability to predict therapeutic failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This was a prospective, multi\u2010centre study conducted in 3 Brazilian hospitals. Clinical outcome was evaluated along 2\u00a0weeks of treatment, and therapeutic failure was defined as the occurrence of persistent candidemia, <jats:italic>Candida<\/jats:italic> deep\u2010seated infection or death. Baseline BDG detection was performed with the Fungitell<jats:sup>\u00ae<\/jats:sup> assay (Associates of Cape Cod, Falmouth\u2014USA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled a total of 71 patients with candidemia and a control group with 110 healthy volunteers. The sensitivity and specificity of BDG for diagnosing candidemia were as follows: 71.8% (95% confidence interval [95% CI] 59.7% \u2010 81.5%) and 98.2% (95% CI 92.9% \u2010 99.7%), respectively. The only predictor of therapeutic failure was a higher BDG value at diagnosis of candidemia; a value\u00a0&gt;\u00a0226\u00a0pg\/mL predicted failure with sensitivity and specificity of 75% and 78%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A high baseline serum BDG value was associated with therapeutic failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13224","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T08:36:42Z","timestamp":1607071002000},"page":"264-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["(1,3)\u2010\u03b2\u2010D\u2010glucan is able to predict therapeutic failure of patients with candidemia and not only mortality"],"prefix":"10.1111","volume":"64","author":[{"given":"Patr\u00edcia","family":"Esteves","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraia","family":"Lopes Lima","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-6468","authenticated-orcid":false,"given":"Analy","family":"Salles de Azevedo Melo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Maria Beir\u00e3o","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-0014","authenticated-orcid":false,"given":"Marcio","family":"Nucci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-8491","authenticated-orcid":false,"given":"Arnaldo L.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine Universidade Federal de S\u00e3o Paulo (UNIFESP) S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3400-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30304-3"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/421944"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/504810"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12380"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq206"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-7-103"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc10507"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv090"},{"issue":"1","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s13054-017-1763-5","article-title":"Del Bono V, ISGRI\u2010SITA (Italian Study Group on Resistant Infections of the Societ\u00e0 Italiana Terapia Antifettiva). 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