{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:53:06Z","timestamp":1792612386994,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of candidemia in our hospital has been stable over an 18\u2010year period (1.3 episodes per 1000 admissions). Since March 2020, we have observed an increase in cases of candidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In March 2020, the hospital was prepared to receive patients with COVID\u201019, with cancellation of elective procedures, discharge of less sick patients and the activation of beds for COVID\u201019. We compared the incidence of candidemia in 2 periods: from January 2019 to February 2020 (period 1) and from March to September 2020 (period 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We diagnosed 41 episodes of candidemia, 16 in period 1 and 25 in period 2 (9 COVID\u201019 patients). Compared with non\u2010COVID\u201019 patients, COVID\u201019 patients with candidemia were more likely to be under mechanical ventilation (100% vs. 34.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The median number of monthly admissions in period 1 and 2 was 723 (interquartile range 655\u2010836) and 523 (interquartile range 389\u2010574), respectively. The incidence of candidemia (per 1000 admissions) was 1.54 in period 1 and 7.44 in period 2 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). In period 2, the incidence of candidemia (per 1000 admissions) was 4.76 if we consider only cases of candidemia in non\u2010COVID\u201019 patients, 2.68 if we consider only cases of candidemia in COVID\u201019 patients and 14.80 considering only admissions of patients with COVID\u201019.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The increase in the incidence of candidemia in our hospital may be attributed to 2 factors: a reduction in the number of admissions (denominator) and the occurrence of candidemia in COVID\u201019 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13225","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T14:57:55Z","timestamp":1607093875000},"page":"152-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":169,"title":["Increased incidence of candidemia in a tertiary care hospital with the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4867-0014","authenticated-orcid":false,"given":"Marcio","family":"Nucci","sequence":"first","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Barreiros","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Felipe","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor A.S.","family":"Deriquehem","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Carla","family":"Casti\u00f1eiras","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone A.","family":"Nou\u00e9r","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Clementino Fraga Filho University Hospital Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13177"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa502"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00801-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3400-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059373"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.5394"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.07.041"},{"key":"e_1_2_7_10_1","article-title":"Candidemia in COVID\u201019 patients: incidence and characteristics in a prospective cohort compared to historical non\u2010COVID\u201019 controls","author":"Mastrangelo A","year":"2020","journal-title":"Clin Infect 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