{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:01:34Z","timestamp":1767895294597,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection among solid organ transplantation. The occurrence of PJP is dangerous and fatal if there is no early identification and sufficient treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the risk factors and provide appropriate strategies of prophylaxis and treatment for PJP after kidney transplantation in our centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>From January 2009 to December 2018, a total of 167 kidney transplantation recipients with pneumonia were enrolled, including 47 PJP patients as PJP group and 120 non\u2010PJP patients as control group. The clinical characteristics of the two groups were analysed retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariate analysis showed that high total dosage of ATG [OR, 2.03; 95% CI, 1.12\u20133.68] and cytomegalovirus (CMV) infection were independent risk factors for PJP. Trimethoprim\u2010sulfamethoxazole (TMP\u2010SMX) (1.44\u00a0g q6h)\u2013based treatment was used for 2\u00a0weeks, and its dosage and course were adjusted according to the therapeutic effect and side effects. Forty\u2010five cases were recovered after 3\u00a0months of follow\u2010up, and two patients died of respiratory failure. TMP\u2010SMX (0.48\u00a0g\/day) prophylaxis was used for 3\u20136\u00a0months and prolonged to 7\u20138\u00a0months after treatment for acute rejection, which reduced the incidence of PJP compared with those without prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that the high total dosage of ATG and CMV infection indicate the increased risk of PJP. The strategies of prophylaxis and treatment for PJP after kidney transplantation in our centre were effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13235","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T03:18:19Z","timestamp":1608866299000},"page":"495-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The risk factor analysis and treatment experience in pneumocystis jirovecii pneumonia after kidney transplantation"],"prefix":"10.1111","volume":"64","author":[{"given":"Pengfeng","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixiang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-8866","authenticated-orcid":false,"given":"Ruiming","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Renal Transplantation The Third Affiliated Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016650107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2003.00018.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12735"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.573"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/339548"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13339"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12823"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2016.11.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr048"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"36","article-title":"European best practice guidelines for renal transplantation. 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