{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T17:24:46Z","timestamp":1748539486974,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,1,31]],"date-time":"2021-01-31T00:00:00Z","timestamp":1612051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The body of evidence on cutaneous mucormycosis is largely derived from case reports or single\u2010centre databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our study aimed to describe incidence, predisposing factors and inpatient outcomes of cutaneous mucormycosis in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based retrospective study using the National Inpatient Sample 2016\u201017 data. Fifty\u2010six discharges had a diagnosis of cutaneous mucormycosis on the International Classification of Diseases, tenth revision. Descriptive analysis was performed for the demographics, predisposing factors, length of stay (LOS), cost and inpatient mortality. The NIS represents 20% of all discharges in the United States, which allowed us to estimate the national incidence of cutaneous mucormycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An estimated total of 280 admissions occurred between 2016 and 2017, indicating 3.9 cases per million admissions across the United States. The estimated incidence rate was 0.43 cases per million people per year. Median age\u00a0was 49.5 (19\u201359) years, 44.6% were female, and 54.9% were Caucasian. We identified haematologic malignancies (48.2%) and solid organ transplantations (10.7%), often accompanied by skin\/soft tissue or post\u2010procedural infections, were the most common predisposing conditions. Median LOS was 15 (6\u201331) days, median total charges were 187,030 (65,962\u2013446,265) USD, and in\u2010hospital mortality rate\u00a0was 16.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In current clinical practice, physicians may encounter cutaneous mucormycosis most commonly in severely immunocompromised hosts with haematologic malignancies or transplantations, accompanied by skin\/soft tissue or post\u2010procedural infections. A high index of suspicion and prompt tissue sampling in at\u2010risk groups is important to improve the outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13245","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T02:32:06Z","timestamp":1611282726000},"page":"569-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence, predisposing conditions and outcomes of cutaneous mucormycosis: A national database study"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-0795","authenticated-orcid":false,"given":"Hirotaka","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corey M.","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine King's Daughter's Health Madison IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kishore","family":"Karri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2012.01.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090334"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179136"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.07.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02979.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.1.67"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/27.5.1138"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/432579"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2023-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20176614"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03456.x"},{"volume-title":"Healthcare Cost and Utilization Project (HCUP)","year":"2020","author":"HCUP Databases","key":"e_1_2_8_13_1"},{"volume-title":"Healthcare Cost and Utilization Project (HCUP)","year":"2020","author":"DUA Training \u2013 Accessible Version","key":"e_1_2_8_14_1"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13245","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:12:38Z","timestamp":1693631558000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,31]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/myc.13245"],"URL":"https:\/\/doi.org\/10.1111\/myc.13245","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2021,1,31]]},"assertion":[{"value":"2020-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}