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Clinical\u2010epidemiological studies demonstrated that non\u2010dermatophyte molds and yeasts are the primary causative agents in 20%\u201330% of onychomycoses. Mixed infections with dermatophytes are observed as well. Therefore, the causative agents should be determined by fungal culture and the antifungal treatment regimen should reliably cover non\u2010dermatophytes, if appropriate. Systemic\u2010topical combination therapy involving a broad\u2010spectrum, locally applied antifungal may increase the mycological and clinical cure rates compared to monotherapy with systemic drugs.<\/jats:p>","DOI":"10.1111\/myc.13251","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T12:57:40Z","timestamp":1612529860000},"page":"694-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Non\u2010dermatophyte fungi in onychomycosis\u2014Epidemiology and consequences for clinical practice"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-4897","authenticated-orcid":false,"given":"Dieter","family":"Reinel","sequence":"first","affiliation":[{"name":"Praxis f\u00fcr Dermatologie Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1679337"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12925"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0403-4"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.05877.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12323"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16394"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1992.tb00281.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0059-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.038"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.40543"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12854"},{"key":"e_1_2_5_13_1","first-page":"659","article-title":"Prevalence, Risk Factors, and Type of Organism in Fungal Foot Infection and Toenail Onychomycosis in Thai Diabetic Patients","volume":"99","author":"Assadamongkol R","year":"2016","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5020035"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.29252\/cmm.3.4.26"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9209-5"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-6012.ijrms20171825"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2014.02.002"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00470749"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12873"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-017-0222-9"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12681"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70112-1"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1119781"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00115-17"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2008.01.023"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12638"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000277762"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90129-4"},{"key":"e_1_2_5_30_1","unstructured":"Summary of product characteristics:fluconazole capsules; 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