{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:25:18Z","timestamp":1790364318415,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The genus <jats:italic>Blastobotrys<\/jats:italic> consists of at least 20 species. Disease in humans has been reported with <jats:italic>B\u00a0adeninivorans, B\u00a0raffinosifermentans, B\u00a0proliferans<\/jats:italic> and <jats:italic>B\u00a0serpentis<\/jats:italic>, mostly in immunocompromised patients and those with cystic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We report a lung infection secondary to <jats:italic>B\u00a0raffinosifermentans<\/jats:italic> in a cystic fibrosis patient successfully treated with isavuconazole and review the literature of invasive infections caused this genus. We also evaluated clinical isolates in our laboratory for species identification and antifungal susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Phylogenetic analysis was performed on a collection of 22 <jats:italic>Blastobotrys<\/jats:italic> isolates in our reference laboratory, and antifungal susceptibility patterns were determined for nine clinically available antifungals against 19 of these isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By phylogenetic analysis, 21 of the 22 isolates in our collection were identified as <jats:italic>B\u00a0raffinosifermentans<\/jats:italic> and only 1 as <jats:italic>B\u00a0adeninivorans<\/jats:italic>. Most were cultured from the respiratory tract, although others were recovered from other sources, including CSF and blood. Isavuconazole, caspofungin and micafungin demonstrated the most potent in vitro activity, followed by amphotericin B. In contrast, fluconazole demonstrated poor activity. The patient in this case responded to isavuconazole treatment for breakthrough infection due to <jats:italic>B\u00a0raffinosifermentans<\/jats:italic> that was cultured from pleural fluid while on posaconazole prophylaxis post\u2013bilateral lung transplantation for cystic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Blastobotrys<\/jats:italic> species are rare causes of infections in humans and primarily occur in immunocompromised hosts. In our collection, the majority of isolates were identified as <jats:italic>B\u00a0raffinosifermentans<\/jats:italic>. To our knowledge, this is the first report of successful treatment of such an infection with isavuconazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13252","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T14:42:32Z","timestamp":1612795352000},"page":"616-623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pulmonary infection secondary to <i>Blastobotrys raffinosifermentans<\/i> in a cystic fibrosis patient: Review of the literature"],"prefix":"10.1111","volume":"64","author":[{"given":"Mohanad","family":"Al\u2010Obaidi","sequence":"first","affiliation":[{"name":"University of Arizona Tucson AZ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-8414","authenticated-orcid":false,"given":"Hamid","family":"Badali","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory Department of Pathology and Laboratory Medicine University of Texas Health Science Center at San Antonio San Antonio TX USA"},{"name":"Invasive Fungi Research Center, Communicable Diseases Institute Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Ca\u00f1ete\u2010Gibas","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory Department of Pathology and Laboratory Medicine University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoja P.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory Department of Pathology and Laboratory Medicine University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":false,"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory Department of Pathology and Laboratory Medicine University of Texas Health Science Center at San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1754-6834-7-66"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-019-1492-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-017-0972-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3767\/003158516X692185"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.002890"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60260-4"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/petr.12294"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01977-14"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00967-07"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.64847-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.012"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy134"},{"key":"e_1_2_8_14_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; 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