{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:31:15Z","timestamp":1778859075123,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ravuconazole is an extended\u2010spectrum triazole agent that is efficient in vitro against <jats:italic>Candida<\/jats:italic> spp. and has been approved to work as an oral formulae for onychomycosis in Japan in 2018. However, nobody had determined the MIC of ravuconazole against the <jats:italic>Candida auris<\/jats:italic>, which is known as an emerging multidrug\u2010resistant yeast. Meanwhile, rare is known of the in vitro activity of ravuconazole against vaginal <jats:italic>Candida<\/jats:italic> isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the activity of ravuconazole against <jats:italic>C.\u00a0auris<\/jats:italic> and vaginal <jats:italic>Candida<\/jats:italic> isolates of China and assess the feasibility of ravuconazole in the treatment of candidiasis caused by <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>auris<\/jats:italic> and other <jats:italic>Candida<\/jats:italic> spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We determined the in vitro activity of ravuconazole and 9 comparators against 15 <jats:italic>C.\u00a0auris<\/jats:italic> isolates and determined the MIC of ravuconazole on 525 vaginal <jats:italic>Candida<\/jats:italic> isolates (<jats:italic>Candida albicans, Candida tropicalis, Candida glabrata and Candida parapsilosis<\/jats:italic>) from 9 provinces of China by Clinical and Laboratory Standards Institute (CLSI) methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The MICs of fluconazole and amphotericin B on <jats:italic>C.\u00a0auris<\/jats:italic> were much higher than second\u2010generation azoles and echinocandins. Ravuconazole was active against all the <jats:italic>C.\u00a0auris<\/jats:italic> isolates and as effective as isavuconazole, posaconazole and echinocandins while showed a better antifungal activity than itraconazole, voriconazole to <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>auris<\/jats:italic>. For vaginal <jats:italic>Candida<\/jats:italic> isolates, the proportion of ravuconazole\u2010resistant isolates is 0.19% (1\/525).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ravuconazole was in good active against <jats:italic>C.\u00a0auris<\/jats:italic> and vaginal <jats:italic>Candida<\/jats:italic> isolates, which suggested ravuconazole could be used in the treatment of drug\u2010resistant candidiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13260","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T14:31:14Z","timestamp":1613831474000},"page":"651-655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In Vitro activity of ravuconazole against <i>Candida auris<\/i> and vaginal candida 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