{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:39:26Z","timestamp":1788273566660,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Candida<\/jats:italic> bloodstream infections (BSI) became an important invasive disease in the late 20th century, in particular among immunocompromised patients. Although considerable progress has been made in the management of patients with invasive mycoses, <jats:italic>Candida<\/jats:italic> BSI are still widespread among hospitalised patients and are associated with relatively high mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted a retrospective study to evaluate patient characteristics, incidence, species distribution and antifungal susceptibility of BSI isolates of <jats:italic>Candida<\/jats:italic> spp. as well as outcomes of <jats:italic>Candida<\/jats:italic> BSI from 2001 to 2012, before the widespread use of echinocandins. This is the first epidemiological study of <jats:italic>Candida<\/jats:italic> BSI in Slovenia so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All documented candidaemia cases from 2001 to 2012 in two major hospitals\u2014University Medical Centre and Institute of Oncology in Ljubljana, Slovenia\u2014were taken into consideration. <jats:italic>Candida<\/jats:italic> BSI were identified in 422 patients (250 male, 172 female). Laboratory and clinical data of these patients were retrospectively analysed. Mann\u2010Whitney <jats:italic>U<\/jats:italic> test was used to compare continuous variables and Fisher's exact test or chi\u2010squared test for categorical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>The average incidence of <jats:italic>Candida<\/jats:italic> BSI was 0.524\/10.000 patient\u2010days (0,317\/1000 admissions); 16\/422 were younger than 1\u00a0year and 251\/422 patients were over 60\u00a0years old. The most commonly isolated species were <jats:italic>Candida<\/jats:italic> <jats:italic>albicans<\/jats:italic> and <jats:italic>Candida<\/jats:italic> <jats:italic>glabrata<\/jats:italic>, followed by <jats:italic>Candida<\/jats:italic> <jats:italic>parapsilosis<\/jats:italic>. Majority of the patients had a single episode of <jats:italic>Candida<\/jats:italic> BSI, multiple episodes of <jats:italic>Candida<\/jats:italic> BSI occurred in 18\/434 patients (4.1%); in 25\/434 patients (5.8%) mixed <jats:italic>Candida<\/jats:italic> BSI were observed. Crude 30\u2010day case\u2010fatality rate was 55.4%.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13278","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T08:01:14Z","timestamp":1617177674000},"page":"753-762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Candidaemia in Central Slovenia: A 12\u2010year retrospective survey"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5696-1412","authenticated-orcid":false,"given":"Tadeja","family":"Matos","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Lejko Zupanc","sequence":"additional","affiliation":[{"name":"Department for Infectious Diseases University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Skofljanec","sequence":"additional","affiliation":[{"name":"Zdravstveni zavod Zdravje  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Jazbec","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana Division of Internal Medicine  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Matos","sequence":"additional","affiliation":[{"name":"Institute of Oncology Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polona","family":"Maver Vodi\u010dar","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julija","family":"Germ","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeja","family":"Ciglar","sequence":"additional","affiliation":[{"name":"Department for Infectious Diseases University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-9516","authenticated-orcid":false,"given":"Rok","family":"Tomazin","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Kofol","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manica","family":"Mueller Premru","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateja","family":"Pirs","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e32833e84d2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.04.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/380637"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1315399"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120452"},{"key":"e_1_2_8_8_1","volume-title":"Annual Epidemiological Report 2013. 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