{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:45:45Z","timestamp":1747187145847,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tinea pedis is often chronic or recurrent, but not all individuals are equally susceptible to this infection. Dermatophytes are able to induce the expression of antimicrobial peptides and proteins (AMPs) in human keratinocytes and certain AMPs can inhibit the growth of dermatophytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The focus of this study was to analyse the secretion of relevant AMPs, especially RNase 7, human beta\u2010defensin\u20102 (hBD\u20102) and the S\u2010100 protein psoriasin (S100A7), in patients with confirmed tinea pedis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To verify the diagnosis, skin scales were obtained from all patients (n\u00a0=\u00a013) and the dermatophytes were identified by potassium hydroxide mount, culture and molecular analysis. To determine the AMP concentrations, the lesional skin area of the foot was rinsed with a buffer that was subsequently analysed by ELISA. The corresponding area of the other unaffected foot as well as defined healthy skin areas of the forearm and forehead and samples from age and gender\u2010matched healthy volunteers served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In tinea pedis patients the AMP concentrations were higher in lesional skin than in non\u2010lesional skin and in healthy skin of controls. In particular, concentrations of hBD\u20102 and psoriasin were significantly elevated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The induction of AMPs in tinea pedis might be triggered directly by the dermatophytes; furthermore, attendant inflammation and\/or differentiation processes may play a role. Our results indicate that there is no defect in the constitutive expression and induction of the analysed AMPs by dermatophytes in the epidermis of affected patients. However, it is not known why the elevated AMP concentrations fail to efficiently combat dermatophyte growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13279","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T07:20:35Z","timestamp":1617348035000},"page":"763-770","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Expression of epidermal antimicrobial peptides is increased in tinea pedis"],"prefix":"10.1111","volume":"64","author":[{"given":"Christina Van Anh","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Quincke Research Center University\u2010Hospital Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Quincke Research Center University\u2010Hospital Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heilwig","family":"Hinrichs","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Quincke Research Center University\u2010Hospital Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Beck\u2010Jendroschek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Mycological Laboratory University Hospitals of Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Harder","sequence":"additional","affiliation":[{"name":"EUROIMMUN Medical Laboratory Diagnostic AG L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-9092","authenticated-orcid":false,"given":"Jochen","family":"Brasch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Mycological Laboratory University Hospitals of Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regine","family":"Gl\u00e4ser","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Quincke Research Center University\u2010Hospital Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4075-4603","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Harder","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology Quincke Research Center University\u2010Hospital Schleswig\u2010Holstein, Campus Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2013.09.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.1.supp.138"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1142"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2008.12.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016433"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700346"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46632-0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2012.660203"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093941"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.373"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-018-1637-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-008-9100-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01606.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/1040841X.2013.856853"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12118"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.432"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5364-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.07.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14778"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01904.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-013-2562-9"},{"issue":"10","key":"e_1_2_7_24_1","first-page":"780","article-title":"Pathogenesis of tinea: pathogenesis of tinea","volume":"8","author":"Brasch J","year":"2010","journal-title":"JDDG J Dtsch Dermatol Ges"},{"key":"e_1_2_7_25_1","first-page":"22","volume-title":"Chemical Immunology and Allergy","author":"Harder J","year":"2005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.01.043"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12133"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511197112"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14383-z"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006424"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.217"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13166"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207587200"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.109"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/648408"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059531"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/43088"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700788"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat0979"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00478-06"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.498"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.369"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12484041"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700663"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13125"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.55.1.2"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16706"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-019-00816-y"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70322-3"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12056"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13279","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:23:07Z","timestamp":1693390987000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/myc.13279"],"URL":"https:\/\/doi.org\/10.1111\/myc.13279","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2021,5,4]]},"assertion":[{"value":"2021-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}