{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:28:03Z","timestamp":1787855283203,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\u00a0+\u00a0Objectives<\/jats:title><jats:p>The echinocandins, amphotericin B preparations, voriconazole and fluconazole are approved for the treatment of invasive candidiasis, though it remains unclear which agent is most effective. In order to answer this question, we performed a systematic review and network meta\u2010analysis of the randomised controlled trials (RCTs) which evaluated these agents in comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four electronic databases were searched from database inception to 8 October 2020. RCTs comparing triazoles, echinocandins or amphotericin B for the treatment of invasive candidiasis or candidemia were included. Random effect Bayesian network meta\u2010analysis methods were used to compare treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen RCTs met inclusion criteria. Of the 3528 patients included from these trials, 1531 were randomised to receive an echinocandin, 944 to amphotericin B and 1053 to a triazole. For all forms of invasive candidiasis, echinocandins were associated with the highest rate of treatment success when compared to amphotericin B (OR 1.41, 95% CI 1.04\u20131.92) and the triazoles (OR 1.82, 95% CI 1.35\u20132.51). Rank probability analysis favoured echinocandins as the most effective choice 98% of the time.\u00a0Overall survival did not significantly differ between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with invasive candidiasis, echinocandins had the best clinical outcomes and should remain the first\u2010line agents in the treatment of invasive candidiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13290","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T17:29:58Z","timestamp":1619285398000},"page":"1098-1110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Comparative effectiveness of amphotericin B, azoles and echinocandins in the treatment of candidemia and invasive candidiasis: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-9519","authenticated-orcid":false,"given":"Koray K.","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Butler\u2010Laporte","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Infectious Diseases Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Medical Microbiology Department of Laboratory Medicine McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Del Corpo","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taline","family":"Ekmekjian","sequence":"additional","affiliation":[{"name":"Medical Libraries McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Infectious Diseases Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Medical Microbiology Department of Laboratory Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"McGill Interdisciplinary Initiative in Infection and Immunity Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Infectious Diseases Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"McGill Interdisciplinary Initiative in Infection and Immunity Montr\u00e9al QC Canada"},{"name":"Clinical Practice Assessment Unit McGill University Health Centre Montr\u00e9al QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Infectious Diseases Department of Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"Division of Medical Microbiology Department of Laboratory Medicine McGill University Health Centre Montr\u00e9al QC Canada"},{"name":"McGill Interdisciplinary Initiative in Infection and Immunity Montr\u00e9al QC 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