{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:33Z","timestamp":1790162913762,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["C002010002"],"award-info":[{"award-number":["C002010002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Talaromyces marneffei<\/jats:italic>, formerly known as <jats:italic>Penicillium marneffei<\/jats:italic>, is a significant emerging pathogenic fungus in Southeast Asia which can generate life\u2010threatening systemic infections. Human immunodeficiency virus (HIV) infection is considered as the most underlying disease among systemic infections. However, infections due to <jats:italic>T.\u00a0marneffei<\/jats:italic> without HIV are increasing in recent years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Research the characteristics of <jats:italic>T.\u00a0marneffei<\/jats:italic> infection in non\u2010HIV individuals in mainland China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we searched Pubmed, China National Knowledge Infrastructure (CNKI) and WanFang from inception to 31 December 2019 for studies reporting <jats:italic>T.\u00a0marneffei<\/jats:italic> infection. Our research concentrates on non\u2013HIV\u2010infected cases and their epidemiology, clinical manifestations, laboratory findings, treatment methods and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>T.\u00a0marneffei<\/jats:italic> infections in non\u2010HIV individuals are increasing. Due to frequent present with atypical symptoms, these non\u2013HIV\u2010infected cases were usually misdiagnosed as other diseases, containing tuberculosis (80.7%), bacterial pneumonia (20.5%), lung cancer (5.1%) or other diseases (5.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>T.\u00a0marneffei<\/jats:italic> infection in non\u2010HIV individuals should be taken seriously. Their symptoms and signs are not typical. Accurate diagnosis and timely antifungal agent treatment is the key to the treatment for the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13295","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T19:25:35Z","timestamp":1623353135000},"page":"1170-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["<i>Talaromyces marneffei<\/i> infection in non\u2013HIV\u2010infected patients in mainland China"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-5189","authenticated-orcid":false,"given":"Liya","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China"},{"name":"Department of Dermatology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou 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