{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:11:57Z","timestamp":1791465117362,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Reports of COVID\u201019 associated pulmonary aspergillosis (CAPA) are rising, but the associated mortality and factors affecting it are not well\u2010characterised. We performed a systematic review including 20 peer\u2010reviewed English language studies reporting mortality in CAPA published till 18 February 2021from PubMed, Ovid SP, Web of Science, Embase and CINHAL. The pooled mortality in CAPA was 51.2% (95% CI: 43.1\u201361.1,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a038%). The leave one out sensitivity analysis and influential case diagnostics revealed one outlier and its exclusion resulted in a mortality estimate of 54% (95% CI: 45\u201362). Higher odds of mortality: 2.83 (95% CI: 1.8\u20134.5) were seen in CAPA compared to controls. No significant difference in various subgroups according to the country of study, the continent of study, income category of country and quality of the included study was seen. None of the host risk factors, mycological test results, therapy for COVID\u201019 and antifungal therapy affected mortality. Thus, patients with CAPA have a high probability of mortality and early diagnosis with prompt therapy must be ensured to optimally manage these patients. However, more prospective studies with global and multi\u2010centre coordination may help to address CAPA in a better way.\n                  <\/jats:p>","DOI":"10.1111\/myc.13328","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T04:41:46Z","timestamp":1622436106000},"page":"1015-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mortality in critically ill patients with coronavirus disease 2019\u2010associated pulmonary aspergillosis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"64","author":[{"given":"Shreya","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipun","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Hepatology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimjhim","family":"Kanaujia","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-9253","authenticated-orcid":false,"given":"Shivaprakash M.","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Postgraduate Institute of Medical Education and Research (PGIMER)  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00028-20"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"VakiliK FathiM PezeshgiA et\u00a0al.Reviews in Cardiovascular Medicine.2020;21:433\u2010442.https:\/\/doi.org\/10.31083\/j.rcm.2020.03.12","DOI":"10.31083\/j.rcm.2020.03.129"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.046"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.06.013"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200160"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/318483"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186422"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.02.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/592256"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241742"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0243124"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0502"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26050"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26424"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10078-2"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30847-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201111-1978OC"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06091-6"},{"key":"e_1_2_11_22_1","unstructured":"WellsG SheaB O'ConnellD et\u00a0al.The Newcastle\u2010Ottawa Scale (NOS) for assessing the quality of non\u2010randomised studies in meta\u2010analyses.2021.http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. 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