{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:35:28Z","timestamp":1784907328740,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological studies indicate that onychomycosis may affect up to 79% of psoriatic patients. Onychomycosis in psoriatic patients is more commonly caused by yeasts comparing with non\u2010psoriatic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Evaluate the prevalence of fungi in nail psoriasis. Evaluate the association between direct mycological examination (DME) and mycological culture, Nail Psoriasis Severity Index (NAPSI) and systemic treatment for psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 133 nails from 20 patients with nail psoriasis were evaluated as follows: 9 patients were using topical treatment and 11 were on systemic treatment. The assessment of psoriasis severity using NAPSI was performed in all psoriatic nails. The presence of fungi was confirmed in DME and culture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DME showed the presence of fungal elements in 45 nails (33.83%) with a predominance of blastoconidia (95.5%) No septate hyphae were seen. Mycological culture was positive in 36 (27.06%) samples. Among them, Candida grew in 31 (86.1%):<jats:italic>Candida parapsilosis<\/jats:italic>in 15 (48.38%),<jats:italic>Candida<\/jats:italic>spp in 14 (45.16%). No growth of dermatophytes was observed. Patients with systemic treatment showed a higher frequency of positive test (DME and culture) for fungi when compared to topic treatment (p:.006). There was a positive correlation between NAPSI, mycological culture and systemic treatment (p:.0063); the risk was four times higher (OR:4.0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitation of the study<\/jats:title><jats:p>Sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results are consistent with some previous reports, Candida was the fungus with higher frequency on the psoriatic nails, however, the role of these fungi is controversial (contamination x colonisation x infection). The fact that the immunosuppressive treatment increases the chance of fungal infection leads us to a greater attention to this patient profile, to prevent the intensification of nail psoriasis (K\u00f6bner phenomenon).<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13331","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T08:54:33Z","timestamp":1622537673000},"page":"1092-1097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Coexistence of onychomycosis and nail psoriasis and its correlation with systemic treatment"],"prefix":"10.1111","volume":"64","author":[{"given":"Rachel","family":"Grynszpan","sequence":"first","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Barreiros","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene","family":"do Nascimento Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Frasnelli Fernandes","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Aguinaga","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia","family":"Camargo","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Ramos\u2010e\u2010Silva","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueli","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinics Post\u2010Graduation Program School of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Medical Specialties Department Post Graduation Course Sector of Dermatology State University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"RigopoulosD TostiA eds.Nail Psoriasis: From A to Z.1st edn.Switzerland:Springer;2014:102\u2010107. ISBN:978\u20103\u2010319\u201008810\u20105.10.1007\/978\u20103\u2010319\u201008810\u20105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2017.68299"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12239"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007229"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1222.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050051335"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239648"},{"key":"e_1_2_10_9_1","first-page":"243","article-title":"Nail psoriasis","volume":"97","author":"Wolska H","year":"2010","journal-title":"Przegl Dermatol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0323"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02568.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2013.783561"},{"key":"e_1_2_10_13_1","first-page":"220","article-title":"The influence of antimicrobial peptides on Candida biofilm","volume":"15","author":"Dawgul M","year":"2010","journal-title":"Allergy Astma Immunol"},{"issue":"6","key":"e_1_2_10_14_1","first-page":"21","article-title":"The role of antimicrobial peptides in chronic inflammatory skin diseases","volume":"33","author":"Marcinkiewicz M","year":"2016","journal-title":"Postep Dermatol Alergol"},{"key":"e_1_2_10_15_1","first-page":"227","article-title":"The role of antimicrobial peptides in selected dermatoses","volume":"103","author":"B\u0142a\u017cewicz I","year":"2016","journal-title":"Przegl Dermatol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1969.01610230059011"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1959.01560170022005"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00910-1"},{"key":"e_1_2_10_20_1","first-page":"1126","volume-title":"Atlas of Clinical Fungi","author":"De Hoog GS","year":"2000"},{"key":"e_1_2_10_21_1","first-page":"1055","volume-title":"The Yeasts, a Taxonomic Study","author":"Kurtzman CP","year":"1998"},{"key":"e_1_2_10_22_1","first-page":"29","article-title":"Onychomycosis","volume":"8","author":"Zepietowski J","year":"2001","journal-title":"NowaMedycyna"},{"key":"e_1_2_10_23_1","first-page":"102","article-title":"The human nail. Structure, growth and pathological changes","volume":"9","author":"Runne U","year":"1981","journal-title":"CurrProbl Dermatol"},{"issue":"5","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/idoj.IDOJ_192_17","article-title":"Coexistence of fungal infections in psoriatic nails and their correlation with severity of nail psoriasis","volume":"9","author":"Chaowattanapanit S","year":"2018","journal-title":"Indian Dermatol Online J"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6771624.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-002-0143-0"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.72468"},{"key":"e_1_2_10_28_1","first-page":"436","article-title":"Onychomycosis in patients with psoriasis","volume":"63","author":"Staberg B","year":"1983","journal-title":"Acta DermVenereol"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02215.x"},{"issue":"4","key":"e_1_2_10_30_1","first-page":"340","article-title":"Onychomycosis in psoriatic patients \u2010 rationalization of systemic treatment","volume":"53","author":"Shemer A","year":"2009","journal-title":"Mycoses"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2007.01405.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-009-9212-x"},{"key":"e_1_2_10_33_1","first-page":"7209519","article-title":"Onychomycosis in psoriatic patients with nail disorders: aetiological agents and immunosuppressive therapy","volume":"2020","author":"Alves NCPOP","year":"2020","journal-title":"Deramatol Res Pract"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-020-00394-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpm.2004.06.001"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12042"},{"issue":"2","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1439-0507.2011.02053.x","article-title":"Onychomycosis in patients with psoriasis \u2010 a multicentre study","volume":"55","author":"Zisova L","year":"2011","journal-title":"Mycoses"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb15764.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12542"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T11:00:30Z","timestamp":1699095630000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,4]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/myc.13331"],"URL":"https:\/\/doi.org\/10.1111\/myc.13331","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,4]]},"assertion":[{"value":"2021-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}