{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T13:13:22Z","timestamp":1793366002569,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe COVID\u201019 patients in ICU are at high risk for candidemia due to exposure to multiple risk factors for candidemia. We aimed to compare the incidence of candidemia in ICU patients with and without COVID\u201019, and to investigate epidemiologic and clinical characteristics of candidemia patients and risk factors for mortality in candidemia patients. This retrospective study was conducted in patients followed in the ICUs of Ankara City Hospital for 2\u00a0years, divided into pre\u2010pandemic and pandemic periods. The incidence (event per 1000 patient\u2010days) and epidemiology of candidemia, clinical and laboratory characteristics of patients were compared in COVID\u201019 and non\u2010COVID\u201019 groups. Candidemia incidence was higher in the COVID\u201019 group (2.16, 95% CI 1.77\u20132.60) than the non\u2010COVID\u201019 group (1.06, 95% CI 0.89\u20130.125) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). A total of 236 candidemia episodes (105 in COVID\u201019 patients and 131 in non\u2010COVID\u201019 patients) were detected during the study periods. COVID\u201019 cases had a higher rate of corticosteroid use (63.8% vs. 9.9%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Epidemiology of candidemia and antifungal susceptibility were similar. Candidemia developed 2\u00a0weeks earlier in COVID\u201019 groups and resulted in higher mortality (92.5% vs. 79.4%, <jats:italic>p<\/jats:italic> .005). One\u2010third of candidemia patients died before receiving any antifungal treatment, and this rate was higher in the COVID\u201019 group. In multivariate logistic regression analysis, corticosteroid use, presence of sepsis and age older than 65\u00a0years were independent risk factors for mortality in candidemia patients. Candidemia with high mortality is a more serious problem for COVID\u201019 patients due to its increased incidence, earlier occurrence and a higher rate of mortality.<\/jats:p>","DOI":"10.1111\/myc.13332","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T07:42:10Z","timestamp":1622792530000},"page":"1083-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["Characteristics of candidemia in COVID\u201019 patients; increased incidence, earlier occurrence and higher mortality rates compared to non\u2010COVID\u201019 patients"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-8319","authenticated-orcid":false,"given":"Bircan","family":"Kayaaslan","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital Ankara 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