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The present systematic review was undertaken to provide an up\u2010to\u2010date summary of the hitherto available literature on CAM. PubMed, Scopus and Google Scholar databases were systematically searched using appropriate keywords till 14 May 2021, to identify case reports\/case series pertaining to mucormycosis in patients with COVID\u201019. Relevant data extracted included demographic characteristics, comorbidity profile, clinical category of mucormycosis, glucocorticoid use, treatment offered and patient outcome. We identified 30 case reports\/case series, pooling data retrieved from 99 patients with CAM. Most cases were reported from India (72%). The majority of the patients was male (78%) and had diabetes mellitus (85%). A prior history of COVID\u201019 was present in 37% patients with mucormycosis developing after an initial recovery. The median time interval between COVID\u201019 diagnosis and the first evidence of mucormycosis infection or CAM diagnosis was 15\u00a0days. Glucocorticoid use was reported in 85% of cases. Rhino\u2010orbital mucormycosis was most common (42%), followed by rhino\u2010orbito\u2010cerebral mucormycosis (24%). Pulmonary mucormycosis was observed in 10 patients (10%). The mortality rate was 34%; the use of adjunct surgery, which was undertaken in 81% of patients, was associated with better clinical outcomes (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). In conclusion, CAM is an emerging problem necessitating increased vigilance in COVID\u201019 patients, even those who have recovered. CAM portends a poor prognosis and warrants early diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/myc.13338","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T16:13:15Z","timestamp":1623859995000},"page":"1452-1459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":237,"title":["COVID\u201019\u2010associated mucormycosis: An updated systematic review of literature"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-9393","authenticated-orcid":false,"given":"Rimesh","family":"Pal","sequence":"first","affiliation":[{"name":"Department of Endocrinology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgurman","family":"Singh","sequence":"additional","affiliation":[{"name":"Resident Doctor Government Medical College Patiala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mainak","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Institute of Postgraduate Medical Education and Research Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjitpal Singh","family":"Bhogal","sequence":"additional","affiliation":[{"name":"Department of Hospital Administration Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neemu","family":"Hage","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery All India Institute of Medical Sciences Bibinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"National Institute of Nursing Education Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2020.09.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.09.032"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010020\u201001561\u2010x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5946\/ce.2020.180"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000001889"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10726"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666\u20105247(20)30115\u20104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_3774_20"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7040298"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idnow.2021.01.010"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.105957"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/11206721211009450"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454\u20105929.ijohns20211583"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121000992"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.645270"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_8_18_1","unstructured":"NIH COVID\u201019 Treatment Guidelines.https:\/\/www.covid19treatmentguidelines.nih.gov\/overview\/clinical\u2010spectrum\/. 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