{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:23:09Z","timestamp":1790745789328,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>An increasing number of reports have described the COVID\u201019\u2013associated pulmonary aspergillosis (CAPA) as being a further contributing factor to mortality. Based on a recent consensus statement supported by international medical mycology societies, it has been proposed to define CAPA as possible, probable, or proven on the basis of sample validity and thus diagnostic certainty. Considering current challenges associated with proven diagnoses, there is pressing need to study the epidemiology of proven CAPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report the incidence of histologically diagnosed CAPA in a series of 45 consecutive COVID\u201019 laboratory\u2010confirmed autopsies, performed at Padova University Hospital during the first and second wave of the pandemic. Clinical data, laboratory data and radiological features were also collected for each case.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Proven CAPA was detected in 9 (20%) cases, mainly in the second wave of the pandemic (7\/17 vs. 2\/28 of the first wave). The population of CAPA patients consisted of seven males and two females, with a median age of 74\u00a0years. Seven patients were admitted to the intensive care unit. All patients had at least two comorbidities, and concomitant lung diseases were detected in three cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a high frequency of proven CAPA among patients with severe COVID\u201019 thus confirming at least in part the alarming epidemiological data of this important complication recently reported as probable CAPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13342","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T15:20:29Z","timestamp":1624375229000},"page":"1223-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Proven COVID\u201019\u2014associated pulmonary aspergillosis in patients with severe respiratory failure"],"prefix":"10.1111","volume":"64","author":[{"given":"Francesco","family":"Fortarezza","sequence":"first","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences, and Public Health, Pathology Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Boscolo","sequence":"additional","affiliation":[{"name":"UOC Institute of Anaesthesia and Intensive Care Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Pezzuto","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences, and Public Health, Pathology Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lunardi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences, and Public Health, Pathology Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Jes\u00fas Acosta","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences, and Public Health, Pathology Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Giraudo","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Tiberio","sequence":"additional","affiliation":[{"name":"Department of Urgency and Emergency University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-5176","authenticated-orcid":false,"given":"Ilaria","family":"Godi","sequence":"additional","affiliation":[{"name":"Department of Urgency and Emergency University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cattelan","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit Padova University Hospital Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Vedovelli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, and Public Health, Biostatistics Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Gregori","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, and Public Health, Biostatistics Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Vettor","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Viale","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences University of Bologna \u2010 Infectious Diseases Unit \u2010 IRCCS Policlinico Sant\u2019Orsola Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Navalesi","sequence":"additional","affiliation":[{"name":"UOC Institute of Anaesthesia and Intensive Care Unit Padova University Hospital Padova Italy"},{"name":"Department of Medicine University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-9226","authenticated-orcid":false,"given":"Fiorella","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic, Vascular Sciences, and Public Health, Pathology Unit University of Padova Medical School Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"528","article-title":"COVID\u201019 Associated pulmonary aspergillosis","volume":"63","author":"Arkel ALE","year":"2020","journal-title":"Am J Respir Crit Care 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