{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:54:32Z","timestamp":1771660472308,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Though invasive pulmonary aspergillosis is a well known complication of COVID\u201019 pneumonia, indolent forms of aspergillosis have been rarely described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively collected the clinico\u2010radio\u2010microbiological data of 10 patients of subacute invasive pulmonary aspergillosis (SAIA), who presented to our hospital with recent history of COVID\u201019 pneumonia along with cavitary lung disease, positive IgG (against <jats:italic>Aspergillus<\/jats:italic>) with or without positive respiratory samples for <jats:italic>Aspergillus spp<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The mean age of presentation of SAIA was 50.7\u00a0\u00b1\u00a011.8\u00a0years. All the patients had recently recovered from severe COVID\u201019 illness with a mean duration of 29.2\u00a0\u00b1\u00a012\u00a0days from COVID\u201019 positivity. Cough was the predominant symptom seen in 8\/10 (80%) patients followed by haemoptysis. 7\/10 (70%) patients were known diabetic. While serum galactomannan was positive in 5\/9 patients (55.5%), fungal culture was positive in 2\/7 patients (28.5%) and polymerase chain reaction (PCR) for <jats:italic>Aspergillus<\/jats:italic> was positive in three patients. Eight (80%) patients presented with a single cavitary lesion; pseudoaneurysm of pulmonary artery was seen in two patients and post\u2010COVID\u201019 changes were seen in all patients. All patients were treated with voriconazole, out of which four (40%) patients died during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SAIA should be considered in the differential diagnosis of cavitating lung lesions in patients with recent history of COVID\u201019 in the background of steroid use with or without pre\u2010existing diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13369","type":"journal-article","created":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T15:51:20Z","timestamp":1632066680000},"page":"57-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["COVID\u201019\u2010associated subacute invasive pulmonary aspergillosis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9466-3531","authenticated-orcid":false,"given":"Satish","family":"Swain","sequence":"first","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9434-5338","authenticated-orcid":false,"given":"Animesh","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Sarda","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surabhi","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Radiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Jorwal","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parul","family":"Kodan","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care All India institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Immaculata","family":"Xess","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naveet","family":"Wig","sequence":"additional","affiliation":[{"name":"Department of Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan","family":"Trikha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Critical Care All India institute of Medical Sciences New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"2459","article-title":"Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID\u201019 antimicrobial prescribing","volume":"71","author":"Rawson TM","year":"2020","journal-title":"Clin Infect Dis off Publ Infect Dis Soc Am"},{"key":"e_1_2_8_3_1","unstructured":"Defining and managing COVID\u201019\u2010associated pulmonary aspergillosis: the 2020 ECMM\/ISHAM consensus criteria for research and clinical guidance \u2010 The Lancet Infectious Diseases [Internet]. [cited 2021 Jun 30]. Available from:https:\/\/www.thelancet.com\/journals\/laninf\/article\/PIIS1473\u20103099(20)30847\u20101\/fulltext"},{"key":"e_1_2_8_4_1","unstructured":"COVID\u201019 Clinical management: living guidance [Internet]. [cited 2021 Aug 30]. Available from:https:\/\/www.who.int\/publications\u2010detail\u2010redirect\/WHO\u20102019\u2010nCoV\u2010clinical\u20102021\u20101"},{"key":"e_1_2_8_5_1","unstructured":"Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management|European Respiratory Society [Internet]. [cited 2021 Jun 24]. 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