{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:48:24Z","timestamp":1792795704665,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903225"],"award-info":[{"award-number":["81903225"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Onychomycosis (OM) is the most common infectious nail disease, and it occurs frequently in patients with psoriasis. Microbial community shifts have been suggested to play a role in psoriasis and fungal infection occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate and compare nail microbial community compositions in psoriatic and nonpsoriatic patients with OM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Toenail samples were collected from nonpsoriatic patients with OM, psoriatic patients with nail psoriasis (NP) and OM, patients with only NP and healthy controls. Bacterial and fungal community compositions were analysed by amplicon sequencing of the V3\u2010V4 regions of the 16S rDNA gene and the ITS1 region, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Psoriatic OM patients had higher bacterial and fungal alpha diversities. Taxonomic analysis revealed a significantly lower relative abundance of\n                      <jats:italic>Trichophyton\u00a0rubrum<\/jats:italic>\n                      (32.88% vs 82.18%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and an increased trend of the abundance of\n                      <jats:italic>Candida<\/jats:italic>\n                      in psoriatic patients with OM than in nonpsoriatic patients. Nonpsoriatic patients with OM had a higher abundance of\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      than healthy controls (59.66% vs 45.76%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05).\n                      <jats:italic>Trichophyton<\/jats:italic>\n                      ,\n                      <jats:italic>Alternaria<\/jats:italic>\n                      and\n                      <jats:italic>Malassezia<\/jats:italic>\n                      could accurately differentiate psoriatic and nonpsoriatic patients with OM, with an area under the curve (AUC) of 0.86. The severity of OM was positively correlated with the relative abundance of\n                      <jats:italic>Trichophyton\u00a0rubrum<\/jats:italic>\n                      . Further,\n                      <jats:italic>Trichophyton<\/jats:italic>\n                      was positively correlated with\n                      <jats:italic>Staphylococcus<\/jats:italic>\n                      and negatively correlated with\n                      <jats:italic>Corynebacterium<\/jats:italic>\n                      ,\n                      <jats:italic>Anaerococcus<\/jats:italic>\n                      ,\n                      <jats:italic>Malassezia<\/jats:italic>\n                      and\n                      <jats:italic>Alternaria<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The nail microbiome in psoriatic patients with OM has distinct bacterial and fungal signatures, suggesting that different dysbiosis is associated with the pathogenesis of OM in psoriatic and nonpsoriatic patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13372","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T06:36:39Z","timestamp":1632292599000},"page":"35-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Characterisation of the nail microbiome in psoriatic and nonpsoriatic patients with onychomycosis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-3086","authenticated-orcid":false,"given":"Shiqi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1644-6942","authenticated-orcid":false,"given":"Yinggai","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis of Dermatoses Beijing China"},{"name":"Research Center for Medical Mycology Peking University Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases Beijing China"},{"name":"NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-1677","authenticated-orcid":false,"given":"Zhe","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital Beijing China"},{"name":"Beijing 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