{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:51:15Z","timestamp":1789764675213,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology of candidemia is evolving with raising concern about the emergence of intrinsically resistant non\u2010<jats:italic>albicans Candida<\/jats:italic> species and acquisition of antifungal resistance. In addition to microbiological surveys, epidemiological studies including clinical data are needed to assess the impact of candidemia on morbidity and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the clinical and microbiological trends of candidemia in a Swiss university hospital.<\/jats:p><jats:p>Patients\/Methods.<\/jats:p><jats:p>This single\u2010centre retrospective study compared the incidence of candidemia, <jats:italic>Candida<\/jats:italic> species distribution, antifungal resistance profiles, clinical characteristics and outcomes between two periods separated by one decade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 170 candidemic episodes were included (68 from period 1, 2004\u20102006, and 102 from period 2, 2014\u20102017). Incidence of candidemia (0.85 to 0.97 episode\/10,000 patient\u2010days), species distribution (55%\u201357% <jats:italic>C albicans<\/jats:italic>) and antifungal susceptibilities remained unchanged. During period 2, candidemia was more frequently observed in intensive care units (ICU, 38% vs 19% in period 1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) and amongst older patients (median age 68 vs 59\u00a0years old, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) with more immunosuppressive conditions (24% vs 9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Candidemia in period 2 was more frequently followed by septic shock (23% vs 7% in period 1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) and ICU admission (42% vs 12%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and was associated with higher mortality (34% vs 18%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03). Overall, factors associated with mortality in multivariate analyses included cirrhosis, solid malignancies and ICU stay at the time of candidemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite stable incidence, species distribution and antifungal resistance of candidemia, an epidemiological shift of the disease towards older and more critically ill patients was observed, with higher mortality rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13376","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T23:14:42Z","timestamp":1632957282000},"page":"1512-1520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Increasing morbidity and mortality of candidemia over one decade in a Swiss university hospital"],"prefix":"10.1111","volume":"64","author":[{"given":"Julien","family":"Battistolo","sequence":"first","affiliation":[{"name":"Infectious Diseases 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Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Pagani","sequence":"additional","affiliation":[{"name":"Adult Intensive Care Service Lausanne University Hospital and University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Eggimann","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology Lausanne University Hospital and University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Yves","family":"Bochud","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine Lausanne University Hospital and University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Calandra","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service Department of Medicine 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