{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:03:50Z","timestamp":1791403430780,"version":"4.3.3"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21fk0108094"],"award-info":[{"award-number":["JP21fk0108094"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several severity indexes have been reported for critically ill patients. The Pitt bacteremia score (PBS) is commonly used to predict the risk of mortality in patients with bacteraemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To develop a scoring system for predicting mortality in candidaemia patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records at five Japanese tertiary hospitals were reviewed. Factors associated with mortality were analysed using logistic regression modelling. The discriminatory power of scoring models was evaluated by assessing the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI) and integrated discrimination improvement (IDI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 422 candidaemia patients were included. Higher PBS, dialysis and retainment of central venous catheter were independent risk factors for all\u2010cause 30\u2010day mortality. However, among the five PBS components, fever was not associated with mortality; therefore, we developed a modified version of the PBS (mPBS) by replacing fever with dialysis. AUC for PBS and mPBS were 0.74 (95% confidence interval [CI]: 0.68\u20130.80) and 0.76 (95% CI: 0.71\u20130.82), respectively. The increase in predictive ability of mPBS for 30\u2010day mortality was statistically significant as assessed by NRI (0.24, 95% CI: 0.01\u20130.46,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.04) and IRI (0.04, 95% CI: 0.02\u20130.06,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0008). When patients were stratified by mPBS into low (scores 0\u20133), moderate (4\u20137) and high risk (\u22658), there were significant differences among the survival curves (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001, log\u2010rank test), and 30\u2010day mortality rates were 13.8% (40\/290), 36.8% (28\/76) and 69.4% (34\/49), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>mPBS can be a useful tool for predicting mortality in candidaemia patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13380","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T18:57:10Z","timestamp":1634497030000},"page":"1498-1507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Modified Pitt bacteremia score for predicting mortality in patients with candidaemia: A multicentre seven\u2010year retrospective study conducted in Japan"],"prefix":"10.1111","volume":"64","author":[{"given":"Nana","family":"Nakada\u2010Motokawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-5758","authenticated-orcid":false,"given":"Taiga","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Nagasaki Japan"},{"name":"Division of Respirology, Rheumatology, Infectious Diseases, and Neurology Department of Internal Medicine Faculty of Medicine University of Miyazaki Miyazaki 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Prevention Kagoshima University Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kakeya","sequence":"additional","affiliation":[{"name":"Department of Infection Control Science Graduate School of Medicine Osaka City University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshige","family":"Mikamo","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases Aichi Medical University Nagakute Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Takesue","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention Hyogo College of Medicine Nishinomiya 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