{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:04:40Z","timestamp":1767924280255,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rhinosporidiosis is a chronic granulomatous disease of the nose caused by <jats:italic>Rhinosporidium seeberi<\/jats:italic>. The disease is largely non\u2010amenable to medical therapy and shows high recurrence rates requiring patients to undergo multiple surgeries often resulting in increased morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse the epidemiological, clinical, histopathological characteristics, treatment and outcome in rhinosporidiosis and to identify factors which predispose to recurrence of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/methods<\/jats:title><jats:p>Retrospective analysis of data of all patients with a diagnosis of rhinosporidiosis confirmed by histopathology at a tertiary care hospital from 2015 to 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 42 patients, 40 males and two females, with a mean age of 37.37\u00a0years. Disease showed bilateral involvement in 17 (40.48%) patients. Nineteen (45.24%) patients had more than two sites involved at initial presentation. Most patients had nasal cavity involvement followed by nasopharynx. Among the 28 patients who had a follow\u2010up, 12 showed recurrent disease. However, 21 patients were disease free following a revision excision. Involvement of more than two sites was an independent significant factor for recurrence. On univariate analysis, other factors which showed statistically significant odds of developing recurrence were previous surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.054), involvement of nasal septum (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.022), middle turbinate (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.024), nasopharynx (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.049) and posterior pharyngeal wall (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.05). Factors which showed significantly less likelihood of developing a recurrence included patients who had less than 12\u00a0months duration from first symptom to intervention (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.016), involvement of less than two sites (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0003) and unilateral disease (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.019).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early intervention in rhinosporidiosis especially when the disease is unilateral and involves less than two sites improves the outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13381","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T00:16:07Z","timestamp":1634429767000},"page":"1471-1479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rhinosporidiosis\u2014Factors predicting disease recurrence"],"prefix":"10.1111","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9281-7071","authenticated-orcid":false,"given":"Lalee","family":"Varghese","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regi","family":"Kurien","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin","family":"Susheel","sequence":"additional","affiliation":[{"name":"Department of Pathology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Cherian","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Rebekah","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9892-0064","authenticated-orcid":false,"given":"Vedantam","family":"Rupa","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Christian Medical College Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"issue":"5","key":"e_1_2_9_2_1","first-page":"04","article-title":"A retrospective epidemiological study of rhinosporidiosis in a rural tertiary care centre in Pondicherry","volume":"10","author":"Karthikeyan P","year":"2016","journal-title":"J Clin Diagn 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