{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:21:35Z","timestamp":1772857295157,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with relapsed\/refractory acute myeloid leukaemia (R\/R AML) who received salvage chemotherapy, limited and not updated studies explored the incidence of invasive aspergillosis (IA) and the role of antifungal prophylaxis (AP). The aims of this multicentre retrospective \u2018SEIFEM 2016\u2010B\u2019 study were as follows: (1) to evaluate the current rate and the outcome of proven\/probable IA and (2) to assess the efficacy of AP, in a large \u2018real life\u2019 series of patient with R\/R AML submitted to salvage chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2250 R\/R AML patients, a total of 74 cases of IA (5.1%) were recorded as follows: 10 (0.7%) proven and 64 (4.3%) probable. Information about AP were available in 73\/74 (99%) patients. Fifty\u2010eight (79%) breakthrough infections occurred, mainly during AP with posaconazole [25 (43%)]. The patients who received AP during salvage chemotherapy showed a benefit from antifungal therapy (AT) than patients who did not received AP [43 (86%) vs 7 (14%); <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.033]. In a multivariate analysis, AP and absence of severe mucositis had a significant favourable effect on overall response rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrated that the incidence of IA during the salvage chemotherapy is similar to the past. Nevertheless, the attributable mortality rate (AMR) appears to be lower than that previously reported in R\/R AML. Further prospective studies should be performed to confirm our preliminary observation and understand and the why a decreased AMR is reported in this setting of high\u2010risk patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13384","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T16:06:07Z","timestamp":1635177967000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Invasive aspergillosis in relapsed\/refractory acute myeloid leukaemia patients: Results from SEIFEM 2016\u2010B survey"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-0669","authenticated-orcid":false,"given":"Maria Ilaria","family":"Del Principe","sequence":"first","affiliation":[{"name":"Cattedra di Ematologia Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u2018Tor Vergata\u2019 Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Dragonetti","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCSS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allegra","family":"Conti","sequence":"additional","affiliation":[{"name":"Sezione di Fisica Medica Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u2018Tor Vergata\u2019 Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Verga","sequence":"additional","affiliation":[{"name":"Clinica Ematologica Ospedale San Gerardo ASST Monza Universit\u00e0 Milano Bicocca Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stelvio","family":"Ballanti","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia Ospedale Santa Maria della Misericordia Universit\u00e0 di Perugia Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Fanci","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Ematologia Ospedale Careggi ed Universit\u00e0 di Firenze Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Candoni","sequence":"additional","affiliation":[{"name":"Clinica di Ematologia e Unit\u00e0 di terapie Cellulari \u2018Carlo Melzi\u2019\u2010Azienda Sanitaria\u2010Universitaria Integrata Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Marchesi","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia ASST\u2010Spedali Civili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Lessi","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia e Immunologia Clinica Universit\u00e0 di Padova Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Fracchiolla","sequence":"additional","affiliation":[{"name":"UOC Ematologia Fondazione IRCCS Ca' Granda\u2010Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Spolzino","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit Azienda Ospedaliero\u2010Universitaria di Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Prezioso","sequence":"additional","affiliation":[{"name":"Hematology and BMT Unit Azienda Ospedaliero\u2010Universitaria di Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Delia","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit\u2010Azienda Ospedaliero\u2010Universitaria Consorziale\u2010Policlinico di Bari Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2738-6105","authenticated-orcid":false,"given":"Leonardo","family":"Potenza","sequence":"additional","affiliation":[{"name":"UOC Ematologia Dipartimento di Scienze Mediche e Chirurgiche Materno infantili e dell'Adulto Universit\u00e0 di Modena e Reggio Emilia Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Decembrino","sequence":"additional","affiliation":[{"name":"UOC Oncoematologia Pediatrica Fondazione IRCCS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Castagnola","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia Fondazione ICRRS Policlinico San Matteo Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpaolo","family":"Nadali","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Ematologia Azienda Ospedaliera Universitaria Integrata diVerona Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Chirurgia Unit\u00e0 di Ematologia Universit\u00e0 Federico II Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Zama","sequence":"additional","affiliation":[{"name":"Pediatric Oncology and Hematology \u2018Lalla Ser\u00e0gnoli\u2019 Pediatric Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Orciulo","sequence":"additional","affiliation":[{"name":"Dipartimento di Oncologia, Trapianti e Tecnologie Avanzate Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Veggia","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia Azienda Ospedaliera San Giovanni Addolorata Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Garzia","sequence":"additional","affiliation":[{"name":"UOC Ematologia\u2010Trapianto cellule staminali Azienda Ospedaliera S.Camillo\u2010Forlanini Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelina","family":"Dargenio","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Ematologia e Trapianto di Cellule Staminali Ospedale Vito Fazzi Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorella","family":"Melillo","sequence":"additional","affiliation":[{"name":"Divisione di Ematologia IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Manetta","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Center AOU Citta' della Salute e della Scienza Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Russo","sequence":"additional","affiliation":[{"name":"Cattedra di Ematologia USD Trapianti di Midollo Osseo per Adulti Spedali Civili di Brescia Universit\u00e0 di Brescia ASST SpedaliCivili di Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mancini","sequence":"additional","affiliation":[{"name":"Dipartimento di Ematologia ed Oncologia Niguarda Cancer Center ASST Grande Ospedale Metropolitano Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Piedimonte","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Molecolare Ematologia Ospedale Universitario Sant'Andrea Universit\u00e0 la Sapienza di Roma Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Chiara","family":"Tisi","sequence":"additional","affiliation":[{"name":"Cell Therapy and Hematology San Bortolo Hospital Vicenza Italy"},{"name":"Divisione di Ematologia Ospedale San Bortolo Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Toschi","sequence":"additional","affiliation":[{"name":"Sezione di Fisica Medica Dipartimento di Biomedicina e Prevenzione Universit\u00e0 degli Studi di Roma \u2018Tor Vergata\u2019 Roma Italy"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging Harvard Medical School Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Busca","sequence":"additional","affiliation":[{"name":"Stem Cell Transplant Center AOU Citta' della Salute e della Scienza Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livio","family":"Pagano","sequence":"additional","affiliation":[{"name":"Istituto di Ematologia Fondazione Policlinico Universitario A. Gemelli\u2010IRCSS\u2010Universit\u00e0 Cattolica del Sacro Cuore Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"behalf of the SEIFEM group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw114"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-516211"},{"key":"e_1_2_8_4_1","first-page":"1068","article-title":"The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM\u20102004 study","volume":"91","author":"Pagano L","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.012054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01979.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01980.x"},{"key":"e_1_2_8_9_1","first-page":"681","article-title":"Risk factors for invasive aspergillosis in acute myeloid leukemia patients prophylactically treated with posaconazole","volume":"49","author":"Michallet M","year":"2011","journal-title":"Med Mycol"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2108-y"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3196-2"},{"issue":"46","key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"15","author":"De Pauw B","year":"2008","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-08-733196"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"issue":"8","key":"e_1_2_8_16_1","first-page":"862","article-title":"Infections caused by filamentous fungi in patients with hematologic malignancies. A report of 391 cases by GIMEMA Infection Program","volume":"86","author":"Pagano L","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw199"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25585"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2019.065"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12960"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13148"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1086\/320757"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx038"},{"key":"e_1_2_8_24_1","first-page":"64","article-title":"Treatment of invasive fungal infections in high risk hematological patients. The outcome with liposomal amphotericin B is not negatively affected by prior administration of mold\u2010active azoles","volume":"26","author":"De la Serna J","year":"2013","journal-title":"Rev Esp Quimioter"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku227"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky550"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12579"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1867-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12213"},{"issue":"10","key":"e_1_2_8_31_1","first-page":"1621","article-title":"Breakthrough invasive mold infections in the hematology patient: current concepts and future directions","volume":"67","author":"Lionakis MS","year":"2018","journal-title":"Clin Infect Dis"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T23:54:03Z","timestamp":1693007643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/myc.13384"],"URL":"https:\/\/doi.org\/10.1111\/myc.13384","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,3]]},"assertion":[{"value":"2021-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}