{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:21:31Z","timestamp":1787797291779,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis patients are more frequently colonised with <jats:italic>Candida species<\/jats:italic>. The correlation between fungal colonisation and clinical severity is unclear, but may exacerbate psoriasis and the impact of antipsoriatic therapies on the prevalence of <jats:italic>Candida<\/jats:italic> is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the prevalence of <jats:italic>C\u00a0species<\/jats:italic> in psoriasis patients compared to an age\u2010 and sex\u2010matched control population, we investigated the influence of <jats:italic>Candida<\/jats:italic> colonisation on disease severity, immune cell activation and the interplay on psoriatic treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prevalence of <jats:italic>C\u00a0species<\/jats:italic> was examined in 265 psoriasis patients and 200 control subjects by swabs and stool samples for fungal cultures. Peripheral mononuclear blood cells (PBMCs) were collected from 20 fungal colonised and 24 uncolonised patients and stimulated. The expression of interferon (IFN)\u2010\u03b3, IL\u201017A, IL\u201022 and tumour necrosis factor (TNF)\u2010\u03b1 from stimulated PBMCs was measured by quantitative real\u2010time polymerase chain reaction (qPCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significantly higher prevalence for <jats:italic>Candida<\/jats:italic> was detected in psoriatic patients (p\u00a0\u2264\u00a0.001) compared to the control subjects; most abundant in stool samples, showing <jats:italic>Candida albicans<\/jats:italic>. Older participants (\u226551\u00a0years) were more frequent colonised, and no correlation with gender, disease severity or systemic treatments like IL\u201017 inhibitors was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although <jats:italic>Candida<\/jats:italic> colonisation is significantly more common in patients with psoriasis, it does not influence the psoriatic disease or cytokine response. Our study showed that Candida colonisation is particularly more frequent in patients with psoriasis \u226551\u00a0years of age. Therefore, especially this group should be screened for symptoms of candidiasis during treatment with IL\u201017 inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13399","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T14:19:46Z","timestamp":1637158786000},"page":"247-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of <i>Candida species<\/i> in Psoriasis"],"prefix":"10.1111","volume":"65","author":[{"given":"Kevin","family":"Elsner","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard Karls Universit\u00e4t T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Holstein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls Universit\u00e4t T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Joachim","family":"Hilke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[{"name":"Deptartment of Clinical Epidemiology and Biostatistics Eberhard Karls Universit\u00e4t T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard Karls Universit\u00e4t T\u00fcbingen T\u00fcbingen 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