{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:01Z","timestamp":1747187161300,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Geotrichum<\/jats:italic>spp can be responsible for severe infections in immunocompromised patients. We aim to describe<jats:italic>Geotrichum\u2010<\/jats:italic>related infections in the ICU and to assess risk factors of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective multicentre study, conducted in 14 French ICUs between 2002 and 2018, including critically ill adult patients with proven or probable infection related to<jats:italic>Geotrichum<\/jats:italic>species. Data were obtained from the medical charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients, median age 60\u00a0years IQR [53; 66] were included. Most of the patients had haematological malignancies (78%). The reason for ICU admission was shock in half of the patients (n\u00a0=\u00a019, 53%) and respiratory failure in thirteen patients (36%). Median SOFA score was 8.5 IQR [7; 15]. Time between ICU admission and fungal diagnosis was 2.5\u00a0days [\u22121; 4]. Infection was disseminated in 27 (75%) patients with positive blood cultures in 25 patients (69%). Thirty patients (83%) received curative antifungal treatment in the ICU, in a median time of 1\u00a0day [0;1] after ICU admission. Twenty\u2010four patients (67%) died in the ICU and hospital mortality rate was 69%. The number and extent of organ failures, as represented by SOFA score, were associated with mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates poor outcome in critically ill patients with<jats:italic>Geotrichum\u2010<\/jats:italic>related infections, which encourages a high level of suspicion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13407","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T19:22:29Z","timestamp":1638472949000},"page":"226-232","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Critically ill patients with severe infections related to<i>Geotrichum<\/i>species: A French retrospective multicentre study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-0624","authenticated-orcid":false,"given":"Sandrine","family":"Valade","sequence":"first","affiliation":[{"name":"AP\u2010HP H\u00f4pital Saint\u2010Louis, Medical ICU Universit\u00e9 de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Picard","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation Polyvalente Centre Hospitalier Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse Oncopole Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djamel","family":"Mokart","sequence":"additional","affiliation":[{"name":"Critical Care Department Institut Paoli Calmettes Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Calvet","sequence":"additional","affiliation":[{"name":"Service de Reanimation Medicale Hopital Gabriel Monpied CHU 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Mayaux","sequence":"additional","affiliation":[{"name":"Intensive Care Unit AP\u2010HP Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital Paris University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Argaud","sequence":"additional","affiliation":[{"name":"Medical ICU Edouard Herriot University Hospital Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Sophie","family":"Moreau","sequence":"additional","affiliation":[{"name":"Department of Intensive Care CHU Lille Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Murgier","sequence":"additional","affiliation":[{"name":"Medical\u2010surgical Intensive care unit Saint\u2010Etienne University Hospital Saint Etienne 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