{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:42:12Z","timestamp":1791639732372,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>(1) To describe the incidence, clinical characteristics, treatment and outcome of <jats:italic>Aspergillus<\/jats:italic> Endocarditis (AE) in a nationwide multicentric cohort (GAMES). (2) To compare the AE cases of the GAMES cohort, with the AE cases reported in the literature since 2010. (3) To identify variables related to mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 10 AE cases included in the GAMES cohort (January 2008\u2010December 2018) and 51 cases from the literature published from January 2010 to July 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4528 patients with infectious endocarditis (IE) were included in the GAMES cohort, of them 10 (0.2%) were AE. After comparing our 10 cases with the 51 of the literature, no differences were found. Analysing the 61 AE cases together, 55.7% were male, median age 45\u00a0years. Their main underlying conditions were as follows: prosthetic valve surgery (34.4%) and solid organ transplant (SOT) (19.7%). Mainly affecting mitral (36.1%) and aortic valve (29.5%). Main isolated species were as follows: <jats:italic>Aspergillus fumigatus<\/jats:italic> (47.5%) and <jats:italic>Aspergillus flavus<\/jats:italic> (24.6%). Embolisms occurred in 54%. Patients were treated with antifungals (90.2%), heart surgery (85.2%) or both (78.7%).<\/jats:p><jats:p>Overall, 52.5% died. A greater mortality was observed in immunosuppressed patients (59.4% vs. 24.1%, OR\u00a0=\u00a04.09, 95%CI\u00a0=\u00a01.26\u201313.19, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02), and lower mortality was associated with undergoing cardiac surgery plus azole therapy (28.1% vs. 65.5%, OR\u00a0=\u00a00.22, 95%CI\u00a0=\u00a00.07\u20130.72, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AE accounts for 0.2% of all IE episodes of a national multicentric cohort, mainly affecting patients with previous valvular surgery or SOT recipients. Mortality remains high especially in immunosuppressed hosts and azole\u2010based treatment combined with surgical resection are related to a better outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13415","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T08:00:56Z","timestamp":1640073656000},"page":"362-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>Aspergillus<\/i> endocarditis in the recent years, report of cases of a multicentric national cohort and literature review"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6394-2861","authenticated-orcid":false,"given":"Maricela","family":"Valerio","sequence":"first","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Medicine Department School of Medicine Universidad Complutense de Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6624-7917","authenticated-orcid":false,"given":"Marta","family":"Camici","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Institute of Infectious Diseases Fondazione Policlinico Universitario A. Gemelli IRCCS Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-2248","authenticated-orcid":false,"given":"Marina","family":"Machado","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-8752","authenticated-orcid":false,"given":"Alicia","family":"Galar","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2398-9619","authenticated-orcid":false,"given":"Maria","family":"Olmedo","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Infectious Diseases Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2594-5169","authenticated-orcid":false,"given":"Dolores","family":"Sousa","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas Complejo Hospitalario Universitario La Coru\u00f1a La Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-3787","authenticated-orcid":false,"given":"Isabel","family":"Antorrena\u2010Miranda","sequence":"additional","affiliation":[{"name":"Servicio de Cardiolog\u00eda Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9259-2730","authenticated-orcid":false,"given":"Maria Carmen","family":"Fari\u00f1as","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas Hospital Universitario Marqu\u00e9s de Valdecilla Santander Spain"},{"name":"Servicio de Enfermedades Infecciosas IDIVAL University of Cantabria Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5728","authenticated-orcid":false,"given":"Carmen","family":"Hidalgo\u2010Tenorio","sequence":"additional","affiliation":[{"name":"Servicio de Enfermedades Infecciosas Hospital Universitario Virgen de las Nieves. 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