{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:35:49Z","timestamp":1787495749009,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Critically ill COVID\u201019 patients have a high risk for the development of candidemia due to being exposed to both well\u2010defined classical risk factors and COVID\u201019\u2010specific risk factors in ICU.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In this study, we investigated the incidence of candidemia in critically COVID\u201019 patients, and the independent risk factors for candidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/methods<\/jats:title>\n                    <jats:p>COVID\u201019 patients hospitalised in ICU during 1\u2010year period (August 2020 to August 2021) were included. Clinical and laboratory characteristics of all COVID\u201019 patients, applied treatments, and invasive procedures that may predispose to candidemia were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1229 COVID\u201019 patients, 63 developed candidemia. Candidemia incidence rate was 4.4 episodes per 1000 ICU days. The most common species was\n                      <jats:italic>Candida albicans<\/jats:italic>\n                      (52.3%). Only 37 patients (58.7%) received antifungal therapy. The presence of central venous catheter (OR 4.7, 95% CI 1.8\u201312.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.005), multifocal candida colonisation (OR 2.7, 95% CI 1.4\u20135.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.005), a prolonged ICU stay (\u226514\u00a0days) (OR 1.9, 95% CI 1.08\u20133\u201337,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), the absence of chronic lung disease (OR 0.4, 95% CI 0.1\u20130.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and the absence of corticosteroid use (OR 0.3, 95% CI 0.14\u20130.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001) were significantly associated with candidemia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study filled the knowledge gap in the literature about the impact of COVID\u201019\u2010associated risk factors for the development of candidemia. The classical risk factors for candidemia had a significant effect on candidemia, and contrary to expectations, corticosteroids had a protective effect against the development of candidemia. The results of these studies showing interesting effects of corticosteroids in critically ill COVID\u201019 patients should be confirmed by further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13431","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T09:19:02Z","timestamp":1644830342000},"page":"508-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Incidence and risk factors for COVID\u201019 associated candidemia (CAC) in ICU patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-8319","authenticated-orcid":false,"given":"Bircan","family":"Kayaaslan","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Kaya Kalem","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Asilturk","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclen","family":"D\u00f6nertas","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Hasanoglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruveyda","family":"Korkmazer","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Oktay","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Is\u0131l","family":"Ozkocak Turan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesna","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Neurology Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmet","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara Yildirim Beyazit University Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0270-z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/514955"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2017.04.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13258"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.2648"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13332"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3310-z"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13225"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1594"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000202208.37364.7D"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199412000-00008"},{"key":"e_1_2_8_13_1","volume-title":"Clinical management of COVID\u201019. interim guidance, 27 May 2020","author":"World Health Organization","year":"2020"},{"key":"e_1_2_8_14_1","unstructured":"World Health Organization.Coronavirus disease (COVID\u201019) technical guidance: laboratory testing for 2019\u2010nCoV in humans.2020.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/technical\u2010guidance\/laboratory\u2010guidance. Accessed 20 December 2021."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040286"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab056"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab562"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040211"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.08.081"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2015.03.010"},{"key":"e_1_2_8_24_1","first-page":"ciab635","article-title":"Candidemia and severe COVID\u201019 \u2010 which risk factors are modifiable?","author":"McCarty T","year":"2021","journal-title":"Clin Infect Dis"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14904-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17021"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17022"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17023"},{"issue":"12","key":"e_1_2_8_30_1","first-page":"CD007720","article-title":"Corticosteroids for pneumonia","volume":"12","author":"Stern A","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2006-164"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.021"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T15:43:49Z","timestamp":1692719029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,10]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/myc.13431"],"URL":"https:\/\/doi.org\/10.1111\/myc.13431","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,10]]},"assertion":[{"value":"2022-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}