{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T17:04:08Z","timestamp":1784653448414,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal infection, particularly intraabdominal candidiasis, exerts a negative impact on the outcome of pancreas transplant recipients (PTRs). Optimal antifungal prophylaxis in this context remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010centre retrospective study to compare the incidence of invasive candidiasis during the first 6 post\u2010transplant months in a cohort of 218 PTRs over two periods in which different agents for antifungal prophylaxis were used: fluconazole (Fluco\u2010Px) from March 1995 to June 2012, and micafungin followed by fluconazole (Mica\u2010Px) from July 2012 to December 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152 and 66 PTRs received Fluco\u2010Px and Mica\u2010Px. Mean age was 39.7\u00a0\u00b1\u00a07.8\u00a0years, 56.4% (123\/218) were males, and 85.3% (186\/218) underwent simultaneous pancreas\u2013kidney transplantation. Invasive candidiasis occurred in 21.7% (33\/152) of PTRs under Fluco\u2010Px compared to 24.2% (16\/66) of those under Mica\u2010Px (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.681). Median time from transplantation to infection was 8\u00a0days (interquartile range [IQR]: 6\u201316) under Fluco\u2010Px versus 6.5 (IQR: 3.3\u201315.8) under Mica\u2010Px (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.623). Non\u2010<jats:italic>albicans Candida<\/jats:italic> species comprised 27.5% (11\/40) and 25.0% (4\/16) of episodes under Fluco\u2010Px and Mica\u2010Px respectively (<jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.849). Surgical site infection was the most common form in both groups (82.5% [33\/40] and 87.5% [14\/16]; <jats:italic>p<\/jats:italic>\u2010value\u00a0=\u00a0.954). Multivariable analysis identified cold ischaemia time of the pancreas and kidney grafts, surgical reintervention and insulin requirement after transplantation as risks factor for invasive candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective study did not reveal a significant benefit from the initial use of micafungin\u2010based antifungal prophylaxis over fluconazole among PTRs in terms of invasive candidiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13436","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T13:40:36Z","timestamp":1646833236000},"page":"517-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fluconazole versus micafungin for initial antifungal prophylaxis against <i>Candida<\/i> in pancreas transplant recipients: A comparative study of two consecutive periods"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-7529","authenticated-orcid":false,"given":"Francisco","family":"L\u00f3pez\u2010Medrano","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Department of Medicine Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mu\u00f1oz de la Espada","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Asunci\u00f3n","family":"P\u00e9rez\u2010Jacoiste As\u00edn","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0315-8001","authenticated-orcid":false,"given":"Mario","family":"Fern\u00e1ndez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Department of Medicine Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-3308","authenticated-orcid":false,"given":"Juan Mar\u00eda","family":"Herrero\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Alonso\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"San Juan","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Department of Medicine Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2150-5748","authenticated-orcid":false,"given":"Isabel","family":"Rodr\u00edguez\u2010Goncer","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0238-1364","authenticated-orcid":false,"given":"Amado","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Medicine Universidad Complutense  Madrid Spain"},{"name":"Department of Nephrology Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Manrique","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Department of Surgery Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iago","family":"Justo","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Department of Surgery Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Marcacuzco","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Department of Surgery Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1873-0568","authenticated-orcid":false,"given":"Carmelo","family":"Loinaz","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Department of Surgery Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of General Surgery Digestive Tract and Abdominal Organ Transplantation, Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Department of Surgery Universidad Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-8288","authenticated-orcid":false,"given":"Carlos","family":"Lumbreras","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Department of Medicine Universidad Complutense  Madrid Spain"},{"name":"Department of Internal Medicine Hospital Universitario \u201c12 de Octubre\u201d Instituto de Investigaci\u00f3n Sanitaria Hospital \u201c12 de Octubre\u201d (imas12)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-8255","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Aguado","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases Hospital Universitario \"12 de Octubre\" Instituto de Investigaci\u00f3n Sanitaria Hospital \"12 de Octubre\" (imas12)  Madrid Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC)  Madrid Spain"},{"name":"Department of Medicine Universidad Complutense  Madrid 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