{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T18:30:08Z","timestamp":1772562608417,"version":"3.50.1"},"reference-count":68,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryptococcosis is a common opportunistic infection associated with HIV\/AIDS. The present review systematically describes the clinical and biological aspects of cryptococcosis in the Democratic Republic of Congo (DRC) and estimates its 2020 burden in people living with HIV (PLHIV). Following PRISMA guidelines, we searched online databases for records of cryptococcosis\/<jats:italic>Cryptococcus<\/jats:italic> spp. in the DRC. Meta\u2010analysis was then performed to estimate summary statistics and the corresponding 95% confidence intervals (CI). A total of 30 studies were included. These included 1,018 cryptococcosis patients, including 80.8% with neuromeningeal cryptococcosis (NMC) and predominantly immunocompromised due to HIV\/AIDS (97.6%). The NMC mean prevalence was estimated at 9.63% (95% CI: 5.99\u201314.07). More than one in two patients (52.7%) under treatment died. Monotherapy with fluconazole was the main treatment administered (80.6%). Furthermore, we estimate that about 9,265 (95% CI: 5,763\u201313,537) PLHIV had cryptococcosis in 2020, in DRC; of which about 4,883 (95% CI: 3,037\u20137,134) would have died in the same year. Among isolates in all included studies, 74 strains have been characterised. Of these, 82.4% concerned <jats:italic>Cryptococcus neoformans<\/jats:italic> sensu lato (s.l) (exclusively of serotype A and mostly of molecular types VNI and VNII) and 17.6% concerned <jats:italic>Cryptotoccus gattii<\/jats:italic> s.l (belonging to serotype B\/molecular type VGI). Cryptococcosis remains common with an unacceptably high mortality rate. A large number of PLHIV affected by and dying from cryptococcosis in 2020 demonstrates its heavy burden among the Congolese PLHIV. To mitigate this burden, it is important to improve the quality and accessibility of care for all PLHIV.<\/jats:p>","DOI":"10.1111\/myc.13440","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:38:50Z","timestamp":1648841930000},"page":"580-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cryptococcosis in the Democratic Republic of Congo from 1953 to 2021: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-5068","authenticated-orcid":false,"given":"Bive Bive","family":"Zono","sequence":"first","affiliation":[{"name":"Molecular Biology Service Department of Basic Sciences Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of Congo"},{"name":"Department of Clinical Microbiology National Reference Center for Mycosis Center for Interdisciplinary Research on Medicines University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dacquin Muhandwa","family":"Kasumba","sequence":"additional","affiliation":[{"name":"Molecular Biology Service Department of Basic Sciences Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hippolyte","family":"Situakibanza Nani\u2010Tuma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Department of Tropical Medicine Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Bepouka Izizag","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Department of Tropical Medicine Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of 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Ntambwe","sequence":"additional","affiliation":[{"name":"Molecular Biology Service Department of Basic Sciences Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Pierre","family":"Hayette","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology National Reference Center for Mycosis Center for Interdisciplinary Research on Medicines University of Liege  Liege Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Mvumbi Lelo","sequence":"additional","affiliation":[{"name":"Molecular Biology Service Department of Basic Sciences Faculty of Medicine University of Kinshasa  Kinshasa the Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"270","article-title":"SIDA et 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