{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:38:28Z","timestamp":1791898708933,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW009345"],"award-info":[{"award-number":["D43TW009345"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of chronic pulmonary aspergillosis (CPA) among drug sensitive pulmonary tuberculosis (PTB) patients on optimal therapy with persistent symptoms was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We consecutively enrolled participants with PTB with persistent pulmonary symptoms after 2\u00a0months of anti\u2010TB treatment at Mulago Hospital, Kampala, Uganda, between July 2020 and June 2021. CPA was defined as a positive <jats:italic>Aspergillus<\/jats:italic>\u2010specific IgG\/IgM immunochromatographic test (ICT), a cavity with or without a fungal ball on chest X\u2010ray (CXR), and compatible symptoms &gt;3\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 162 participants (median age 30\u00a0years; IQR: 25\u201340), 97 (59.9%) were male, 48 (29.6%) were HIV\u2010infected and 15 (9.3%) had prior PTB. Thirty\u2010eight (23.4%) sputum samples grew <jats:italic>A.\u00a0niger<\/jats:italic> and 13 (8.0%) <jats:italic>A.\u00a0fumigatus<\/jats:italic> species complexes. Six (3.7%) participants had intracavitary fungal balls and 52 (32.1%) had cavities. Overall, 32 (19.8%) participants had CPA. CPA was associated with prior PTB (adjusted odds ratio [aOR]: 6.61, 95% CI: 1.85\u201323.9, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004), and far advanced CXR changes (aOR: 4.26, 95% CI: 1.72\u201310.52, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). The <jats:italic>Aspergillus<\/jats:italic> IgG\/IgM ICT was positive in 10 (31.3%) participants with CPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chronic pulmonary aspergillosis may cause persistent respiratory symptoms in up to one\u2010fifth of patients after intensive treatment for PTB. The <jats:italic>Aspergillus<\/jats:italic> IgG\/IgM ICT positivity rate was very low and may not be used alone for the diagnosis of CPA in Uganda.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13444","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T07:43:25Z","timestamp":1649922205000},"page":"625-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Chronic pulmonary aspergillosis in patients with active pulmonary tuberculosis with persisting symptoms in Uganda"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-0770","authenticated-orcid":false,"given":"Martha","family":"Namusobya","sequence":"first","affiliation":[{"name":"School of Medicine College of Health Sciences Makerere Lung Institute Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bongomin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology Faculty of Medicine Gulu University  Gulu Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mukisa","sequence":"additional","affiliation":[{"name":"Department of Immunology and Molecular Biology School of Biomedical Sciences College of Health Sciences Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Kane","family":"Olwit","sequence":"additional","affiliation":[{"name":"Department of Radiology School of Medicine College of Health Sciences Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Batte","sequence":"additional","affiliation":[{"name":"School of Medicine College of Health Sciences Makerere Lung Institute Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudine","family":"Mukashyaka","sequence":"additional","affiliation":[{"name":"College of Health Sciences Infectious Diseases Institute Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0587-8181","authenticated-orcid":false,"given":"Emmanuel","family":"Mande","sequence":"additional","affiliation":[{"name":"College of Health Sciences Infectious Diseases Institute Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-3539","authenticated-orcid":false,"given":"Richard","family":"Kwizera","sequence":"additional","affiliation":[{"name":"College of Health Sciences Infectious Diseases Institute Makerere University  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5626-2251","authenticated-orcid":false,"given":"David W.","family":"Denning","sequence":"additional","affiliation":[{"name":"Manchester Fungal Infection Group University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Rhein","sequence":"additional","affiliation":[{"name":"Centre for Global Health and Social Responsibility University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Prasad","sequence":"additional","affiliation":[{"name":"Centre for Global Health and Social Responsibility University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sekaggya\u2010Wiltshire","sequence":"additional","affiliation":[{"name":"College of Health Sciences Infectious Diseases Institute Makerere University  Kampala 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