{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:04:02Z","timestamp":1785546242261,"version":"3.56.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Candida auris<\/jats:italic> is an emerging multidrug\u2010resistant pathogen in intensive care settings (ICU). During the coronavirus disease 19 (COVID\u201019) pandemic, ICU admissions were overwhelmed, possibly contributing to the <jats:italic>C.\u00a0auris<\/jats:italic> outbreak in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present systematic review addresses the prevalence, underlying diseases, iatrogenic risk factors, treatment and outcome of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>auris<\/jats:italic> infections in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MEDLINE, Scopus, Embase, Web of Science and LitCovid databases were systematically searched with appropriate keywords from 1 January 2020 to 31 December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 97 cases of <jats:italic>C.\u00a0auris<\/jats:italic> were identified in COVID\u201019 patients. The pooled prevalence of <jats:italic>C.\u00a0auris<\/jats:italic> infections (encompassing candidemia and non\u2010candidemia cases)\u00a0in COVID\u201019 patients was 14%. The major underlying diseases were diabetes mellitus (42.7%), hypertension (32.9%) and obesity (14.6%), followed by the iatrogenic risk factors such as a central venous catheter (76.8%%), intensive care unit (ICU) stay (75.6%) and broad\u2010spectrum antibiotic usage (74.3%). There were no significant differences in underlying disease and iatrogenic risk factors among <jats:italic>C.\u00a0auris<\/jats:italic> non\u2010candidemia\/colonisation and <jats:italic>C.\u00a0auris<\/jats:italic> candidemia cases. The mortality rate of the total cohort is 44.4%, whereas, in <jats:italic>C.\u00a0auris<\/jats:italic> candidemia patients, the mortality was 64.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that the prevalence of <jats:italic>C.\u00a0auris<\/jats:italic> infections remains unchanged in the COVID\u201019 pandemic. Hospital\u2010acquired risk factors may contribute to the clinical illness. Proper infection control practices and hospital surveillance may stop future hospital outbreaks during the pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13447","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T10:08:52Z","timestamp":1650449332000},"page":"613-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Prevalence, risk factors, treatment and outcome of multidrug resistance <i>Candida auris<\/i> infections in Coronavirus disease (COVID\u201019) patients: A systematic review"],"prefix":"10.1111","volume":"65","author":[{"given":"Kalaiselvi","family":"Vinayagamoorthy","sequence":"first","affiliation":[{"name":"Centre for Public Health (U.I.E.A.S.T) Panjab University  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyana Chakravarthy","family":"Pentapati","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry Manipal College of Dental Sciences, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8296-393X","authenticated-orcid":false,"given":"Hariprasath","family":"Prakash","sequence":"additional","affiliation":[{"name":"Medical Microbiology Department of Public Health International Higher School of Medicine  Cholpon\u2010Ata Kyrgyzstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2020.368"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2021.104806"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7010031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.658329"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8020181"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714373"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02031\u201020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.578"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879\u2010019\u20103999\u2010y"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.29058"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241541"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.12.030"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10020157"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7002e3"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13320"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100384\u20104"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u20103\u201025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBISRIR\u2010D\u201019\u201000099"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v049.i05"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v036.i03"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7030220"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2611.203504"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01146\u201021"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9010095"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab057"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4827"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.1573"},{"key":"e_1_2_9_30_1","unstructured":"Council of State and Territorial Epidemiologists.Standardized case definition forCandida auriscausing clinical infection and colonization in people (17th\u2010ID\u201003). 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