{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:45:07Z","timestamp":1790729107843,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine\u2010resistant strains of <jats:italic>Trichophyton<\/jats:italic> spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to describe the effect of commonplace disinfection methods using socks pieces inoculated with terbinafine\u2010resistant or terbinafine\u2010susceptible isolates of <jats:italic>Trichophyton<\/jats:italic> spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sock pieces were inoculated with seven terbinafine\u2010resistant isolates of <jats:italic>Trichophyton<\/jats:italic> spp<jats:italic>.<\/jats:italic> with known mutations in the SQLE\u2010gene (<jats:italic>T.\u00a0rubrum<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), <jats:italic>T.\u00a0interdigitale<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) and <jats:italic>T.\u00a0indotineae<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03)) and six terbinafine\u2010susceptible isolates of <jats:italic>Trichophyton<\/jats:italic> spp<jats:italic>.<\/jats:italic> (<jats:italic>T.\u00a0rubrum<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) and <jats:italic>T.\u00a0interdigitale<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03)). Methods of disinfection included soaking in a quaternary ammonium (QAC) detergent (0.5, 2 and 24\u00a0h), freezing at \u221220\u00b0C (0.5, 12 and 24 h), domestic and steam washing (both at 40\u00b0C with detergent). Sock pieces were cultured for 4\u2009weeks following disinfection. The primary end point was no growth at the end of week 4.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Soaking in a QAC\u2010detergent for 24\u00a0h procured at disinfectant rate of 100% (13\/13), whilst soaking in 0.5 and 2\u2009h had a disinfectant rate of 46.2% (6\/13) and 84.6% (11\/13), respectively. Domestic washing (40\u00b0C with detergent) produced a disinfectant rate of 7.7% (1\/13). Freezing at \u221220\u00b0C (0.5, 12 and 24\u00a0h) and steam washing (40\u00b0C with detergent) had no disinfectant properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Soaking in a QAC\u2010detergent for 24 h effectively disinfected sock pieces contaminated with dermatophytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13468","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T10:29:04Z","timestamp":1652178544000},"page":"741-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Disinfection trials with terbinafine\u2010susceptible and terbinafine\u2010resistant dermatophytes"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1550-0537","authenticated-orcid":false,"given":"Kristoffer Nagy","family":"Skaastrup","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2540","authenticated-orcid":false,"given":"Gregor Borut Ernst","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-1047","authenticated-orcid":false,"given":"Ditte Marie Lindhardt","family":"Saunte","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital  Roskilde Denmark"},{"name":"Mycology Unit, Department for Microbiology and Infection Control Statens Serum Institut  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health Science University of Copenhagen  Copenhagen 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