{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:35:06Z","timestamp":1782455706537,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human cytomegalovirus (CMV) is associated with aspergillosis, but the simultaneous presence of CMV viral interleukin\u201010 (cmvIL\u201010) and aspergillosis has never been investigated. CmvIL\u201010 is produced by CMV\u2010infected cells and acts as an immune modulator during CMV infection. The aim of this study was to evaluate cmvIL\u201010 levels in peripheral blood and its influence on the clinical outcomes of <jats:italic>Aspergillus<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who visited or were admitted to the hospital with suspected <jats:italic>Aspergillus<\/jats:italic> infection, including invasive aspergillosis (IA) and chronic pulmonary aspergillosis (CPA), were prospectively enrolled. The cmvIL\u201010, human IL\u201010 (hIL\u201010), IL\u20101B, IL\u20106, IL\u20108, IFN\u2010\u03b3, and TNF\u2010\u03b1 levels in peripheral blood were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with <jats:italic>Aspergillus<\/jats:italic> infection had a higher level of cmvIL\u201010 than the control group (158\u2009\u00b1\u2009305 vs 27.9\u2009\u00b1\u200930.4\u00a0pg\/ml, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). The level of cmvIL\u201010 was not correlated with CMV viremia or end\u2010organ disease. The cmvIL\u201010 but not hIL\u201010 level was positively correlated with the IFN\u2010\u03b3 level (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and marginally negatively correlated with IL\u20101B and IL\u20108 levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.1). In patients with CPA, a high level of cmvIL\u201010 (\u2265100\u2009pg\/ml) was a poor prognostic factor for long\u2010term survival (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In contrast, CMV viremia or end\u2010organ disease was associated with poor survival in patients with IA (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>Aspergillus<\/jats:italic> infection was associated with CMV coinfection with cmvIL\u201010 in blood. A cmvIL\u201010 concentration \u2265100\u2009pg\/ml was a predictor for unfavourable outcome in CPA patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13472","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T16:02:56Z","timestamp":1652371376000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytomegalovirus viral interleukin\u201010 in patients with <i>Aspergillus<\/i> infection and effects on clinical outcome"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-9108","authenticated-orcid":false,"given":"Shiang\u2010Fen","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chi","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Te","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Ta","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Department of Chest Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Pai","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of General Medicine, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Endocrinology and Metabolism, Department of Medicine Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Division of Clinical Skills Training, Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dar\u2010Der","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jiun","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Pathology and Laboratory Medicine Taipei Veterans General Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Clinical Skills Training, Department of Medical Education Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Medicine, Institute of Clinical Medicine National Yang Ming Chiao Tung University  Taipei 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