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The objectives of this study were to determine the incidence of and examine factors associated with cryptococcosis after a diagnosis of COVID\u201019. We used TriNetX to identify and sort patients 18\u2009years and older hospitalised with COVID\u201019 into two cohorts based on the presence or absence of a diagnosis of cryptococcosis following diagnosis of COVID\u201019. Outcomes of interest included the incidence of cryptococcosis following the diagnosis of COVID\u201019 as well as the proportion of patients in each group who had underlying comorbidities, received immunomodulatory therapy, required ICU admission or mechanical ventilation (MV), or died. Propensity score matching was used to adjust for confounding. Among 212,479 hospitalised patients with COVID\u201019, 65 developed cryptococcosis. The incidence of cryptococcosis following COVID\u201019 was 0.022%. Patients with cryptococcosis were more likely to be male and have underlying comorbidities. Among cases, 32% were people with HIV. Patients with cryptococcosis were more likely to have received tocilizumab (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) or baricitinib (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), but not dexamethasone (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0840). ICU admission (38% vs 29%), MV (23% vs 11%), and mortality (36% vs 14%) were significantly higher among patients with cryptococcosis. Mortality remained elevated after adjusted propensity score matching. Cryptococcosis occurred most often in hospitalised patients with COVID\u201019 who had traditional risk factors, comparable to findings in patients without COVID\u201019. Cryptococcosis was associated with increased ICU admission, MV, and mortality.<\/jats:p>","DOI":"10.1111\/myc.13476","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T12:18:25Z","timestamp":1654258705000},"page":"815-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cryptococcosis among hospitalised patients with <scp>COVID<\/scp>\u201019: A\u00a0multicentre research network study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4018-0195","authenticated-orcid":false,"given":"Daniel B.","family":"Chastain","sequence":"first","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy University of Georgia College of Pharmacy  Albany Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa M.","family":"Kung","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University 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