{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:15:40Z","timestamp":1781738140361,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T00:00:00Z","timestamp":1656547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological knowledge of mucormycosis obtained from national population\u2010based databases is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to depict the disease burden and demographics of mucormycosis in Taiwan by using the Taiwan National Health Insurance Research Database (NHIRD) and those of aspergillosis as a comparator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from patients with either mucormycosis or aspergillosis from 2006 to 2017 identified with the International Classification of Diseases (ICD) codes were extracted from the NHIRD. The incidence, demographics and clinical data of both diseases were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 204 patients with mucormycosis and 2270 patients with aspergillosis who were hospitalised and treated with mould\u2010active antifungals between 2006 and 2017 were identified. The average annual incidence of aspergillosis (0.81 cases per 100,000 population [0.81\/100,000]) was 11\u2010fold higher than that of mucormycosis (0.07\/100,000). A significant increase in incidence was observed for aspergillosis (from 0.48\/100,000 in 2006 to 1.19\/100,000 in 2017, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) but not for mucormycosis (from 0.04\/100,000 in 2006 to 0.11\/100,000 in 2017, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.07). The major underlying disease identified was diabetes mellitus (60.8%) for mucormycosis and malignant neoplasms (45.9%) for aspergillosis. The all\u2010cause 90\u2010day mortality rate was similar between mucormycosis and aspergillosis patients (39% vs. 37%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.60). For mucormycosis patients, multivariate analysis revealed that posaconazole use was associated with lower in\u2010hospital mortality (aOR 0.38; 95% CI 0.15\u20130.97; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mucormycosis is an uncommon fungal disease in Taiwan, occurring mostly in diabetic patients. However, the incidence might be underestimated due to limited diagnostics. Continuous surveillance might aid in delineating the evolving features of mucormycosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13484","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T14:28:54Z","timestamp":1655476134000},"page":"1001-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Disease burden and demographic characteristics of mucormycosis: A nationwide <scp>population\u2010based<\/scp> study in Taiwan, 2006\u20132017"],"prefix":"10.1111","volume":"65","author":[{"given":"Hsin\u2010I","family":"Shih","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Public Health, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University  Tainan Taiwan"},{"name":"School of Medicine, College of Medicine National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-9088","authenticated-orcid":false,"given":"Chi\u2010Jung","family":"Wu","sequence":"additional","affiliation":[{"name":"National Institute of Infectious Diseases and Vaccinology National Health Research Institutes  Tainan Taiwan"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital College of Medicine, National Cheng Kung University  Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040265"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010026"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1509.090334"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-2930-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12395"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.10.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030523"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S196293"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1408793"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0261871"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-019-0554-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2019.06.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149964"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.03.012"},{"issue":"2","key":"e_1_2_9_16_1","first-page":"107","article-title":"Burden of serious fungal infection in Nigeria","volume":"33","author":"Oladele RO","year":"2014","journal-title":"West Afr J Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-2925-8"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12409"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-2927-6"},{"key":"e_1_2_9_20_1","unstructured":"International Diabetes Federation.IDF diabetes atlas 2021 (tenth edition).https:\/\/diabetesatlas.org. Accessed 31 March 2022."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202809"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7110531"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01230-21"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:59:09Z","timestamp":1692651549000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,30]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/myc.13484"],"URL":"https:\/\/doi.org\/10.1111\/myc.13484","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,30]]},"assertion":[{"value":"2022-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}