{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:24:09Z","timestamp":1781522649635,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>COVID\u201019\u2010associated pulmonary aspergillosis (CAPA) has been widely reported but homogenous large cohort studies are needed to gain real\u2010world insights about the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected clinical and laboratory data of 1161 patients hospitalised at our Institute from March 2020 to August 2021, defined their CAPA pathology, and analysed the data of CAPA\/non\u2010CAPA and deceased\/survived CAPA patients using univariable and multivariable models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall prevalence and mortality of CAPA in our homogenous cohort of 1161 patients were 6.4% and 47.3%, respectively. The mortality of CAPA was higher than that of non\u2010CAPA patients (hazard ratio: 1.8 [95% confidence interval: 1.1\u20132.8]). Diabetes (odds ratio [OR] 1.92 [1.15\u20133.21]); persistent fever (2.54 [1.17\u20135.53]); hemoptysis (7.91 [4.45\u201314.06]); and lung lesions of cavitation (8.78 [2.27\u201334.03]), consolidation (9.06 [2.03\u201340.39]), and nodules (8.26 [2.39\u201328.58]) were associated with development of CAPA by multivariable analysis. Acute respiratory distress syndrome (ARDS) (2.68 [1.09\u20136.55]), a high computed tomography score index (OR 1.18 [1.08\u20131.29]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and pulse glucocorticoid treatment (HR 4.0 [1.3\u20139.2]) were associated with mortality of the disease. Whereas neutrophilic leukocytosis (development: 1.09 [1.03\u20131.15] and mortality: 1.17 [1.08\u20131.28]) and lymphopenia (development: 0.68 [0.51\u20130.91] and mortality: 0.40 [0.20\u20130.83]) were associated with the development as well as mortality of CAPA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a low but likely underestimated prevalence of CAPA in our study. CAPA is a disease with high mortality and diabetes is a significant factor for its development while ARDS and pulse glucocorticoid treatment are significant factors for its mortality. Cellular immune dysregulation may have a central role in CAPA from its development to mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13485","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T15:18:59Z","timestamp":1655565539000},"page":"1010-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["New insights into development and mortality of <scp>COVID\u201019<\/scp>\u2010associated pulmonary aspergillosis in a homogenous cohort of 1161 intensive care patients"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-4554","authenticated-orcid":false,"given":"Zia","family":"Hashim","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafar","family":"Neyaz","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis SGPGIMS  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungmei S. 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