{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:58:41Z","timestamp":1766087921396,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2021A1515110231"],"award-info":[{"award-number":["2021A1515110231"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071265"],"award-info":[{"award-number":["82071265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to compare the epidemiologic, clinical, laboratory, and imaging features, and outcomes in patients with <jats:italic>Cryptococcus gattii<\/jats:italic> meningitis (CGM) and <jats:italic>Cryptococcus neoformans<\/jats:italic> meningitis (CNM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective study of HIV\u2010negative patients with CGM and CNM (2015\u20132021) distinguished by metagenomic next\u2010generation sequencing in cerebrospinal fluid in South China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 81 patients (17 CGM, 64 CNM) were enrolled (72.8% male, median age 49\u2009years, range 21\u201377\u2009years), and CGM patients were younger (median, 43 vs 53\u2009years, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Of 17 CGM, VGI and VGII accounted for 70.6% and 29.4%, respectively. CGM patients had less underlying diseases (7\/17 [41.2%] vs 48\/64 [75%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) and focal neurologic deficit (3\/17 [17.6%] vs 35\/64 [54.7%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.022), had higher intracranial pressure (15\/17 [88.2%] vs 25\/64 [39.1%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), more meningeal enhancement (14\/17 [82.4%] vs 32\/64 [50%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.034), less parenchymal involvement (median, 1 vs 3, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.018), more lung cryptococcomas (6\/12 [50%] vs 6\/47 [12.8%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014), faster CSF fungal clearance (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004), less complications (median, 1 vs 3, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), and more favourable outcomes (16\/17 [94.1%] vs 41\/64 [64.1%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated that species identification helps to guide therapy and predict outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13491","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T18:13:32Z","timestamp":1657131212000},"page":"887-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of features and outcomes between <scp>HIV<\/scp>\u2010negative patients with <i>Cryptococcus gattii<\/i> meningitis and <i>Cryptococcus neoformans<\/i> meningitis in South China"],"prefix":"10.1111","volume":"65","author":[{"given":"Xiao\u2010Hong","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology, Integrated Hospital of Traditional Chinese Medicine Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-6308","authenticated-orcid":false,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Scientific Affairs Hugobiotech Co., Ltd.  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-205X","authenticated-orcid":false,"given":"Fu\u2010Hua","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou 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