{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T16:14:08Z","timestamp":1770567248972,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["WP2485056"],"award-info":[{"award-number":["WP2485056"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["59276319"],"award-info":[{"award-number":["59276319"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist to describe end\u2010of\u2010treatment (EOT) parameters of antifungal therapy for invasive mould infections (IMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a 10\u2010year cohort of consecutive adult allogeneic haematopoietic cell transplant recipients with proven\/probable IMI, we describe treatment duration and patient profile at EOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 61 patients with 66 proven\/probable IMI identified: 47\/66 (71%) invasive aspergillosis (IA), 11\/66 (17%) mucormycosis, and 8\/66 (12%) other\u2010IMI. Excluding 5 (8%) patients lost to follow\u2010up, treatment was prematurely discontinued due to death or palliative care in 29\/56 (51.8%) patients. Antifungal treatment was completed in 27 (48.2%) patients, for a median duration of 280\u2009days (IQR: 110, 809): 258 (IQR: 110, 1905) and 307.5 (99, 809) days in IA and non\u2010IA IMI, respectively. Treatment was continued after 90 and 180\u2009days in 43\/56 (76.8%) and 30\/56 (53.6%) patients, respectively. At EOT, most patients were not neutropenic (ANC: 2.12\u2009G\/L, IQR: 0.04, 5.3), with CD4+ counts at 99 cells\/\u03bcl (IQR: 0, 759) and immunoglobulins at 5.6 g\/L (IQR: 2.3, 10.6). Most patients (16\/27, 59.3%) were not receiving steroids at EOT, while 14\/27 (53.9%) were on another type of immunosuppression. Amongst 15 patients with imaging at EOT, 12 (80%) had complete\/partial radiologic response. Any chart documentation or an infectious disease consultation on treatment discontinuation was observed in 12\/56 (21%) and 11\/56 (20%) patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long treatment courses are observed in patients with IMI, due to prolonged immunosuppression. Although immune reconstitution and radiological response were frequently observed at EOT, consistent documentation of treatment discontinuation based on well\u2010defined parameters is lacking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13496","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:18:56Z","timestamp":1657541936000},"page":"1061-1067","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["When and how do we stop antifungal treatment for an invasive mould infection in allogeneic haematopoietic cell transplant recipients?"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-9636","authenticated-orcid":false,"given":"Romain Samuel","family":"Roth","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases University Hospital of Geneva  Geneva 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Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Morin","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Division of Hematology, University Hospital of Geneva and Faculty of Medicine University of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"van Delden","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University Hospital of Geneva  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Chalandon","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Unit, Division of Hematology, University Hospital of Geneva and Faculty of Medicine University of Geneva  Geneva 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