{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:10:04Z","timestamp":1787508604123,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The development of candidemia is a highly fatal condition in severe COVID\u201019 infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to develop a candidemia prediction score in COVID\u201019 patient based on the patient's clinical characteristics, and healthcare\u2010related factors during intensive care units (ICU) follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Severe COVID\u201019 patients hospitalised in ICU in Ankara City Hospital during the one\u2010year period (August 15, 2020, and August 15, 2021) were included. After univariate analysis, multivariate analysis was applied using variable selection approach to investigate the effects of variables together and to create a score model for candidemia. Statistically significant factors were included in the development process of candida prediction score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 1305 COVID\u201019 ICU patients, 139 had a candidemia episode. According to the final model, four variables, presence of central venous catheter (CVC) (OR 19.07, CI 8.12\u201344.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.0001), multifocal colonisation (OR 2.28, CI 1.39\u20133.72, p 0.001), length of ICU stays \u226514\u2009days (OR 3.62, CI 2.42\u20135.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.0001) and corticosteroids (OR 0.51, CI 0.34\u20130.76, p 0.0011) were the only statistically significant independent risk factors for candidemia. Score model was demonstrated by a nomogram, and the risk for candidemia was calculated to be high in patients who scored \u226556 points by using the criteria [CVC\u00a0=\u00a051, multifocal colonisation\u00a0=\u00a014, prolonged hospitalisation\u00a0=\u00a023, no steroid use\u00a0=\u00a012 points]. The AUC of the score is 0.84 (CI 0.81\u20130.87).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We developed and validated an easy\u2010to\u2010use clinical prediction score for candidemia in severe COVID\u201019 infection. In COVID\u201019 ICU patients, the risk of candidemia is high if one of the other risk factors is present together with CVC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13531","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T08:38:50Z","timestamp":1663835930000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Development and validation of\n                    <scp>COVID<\/scp>\n                    \u201019 associated candidemia score (\n                    <scp>CAC\u2010Score<\/scp>\n                    ) in\n                    <scp>ICU<\/scp>\n                    patients"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5225-8319","authenticated-orcid":false,"given":"Bircan","family":"Kayaaslan","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Eser","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Asilturk","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Oktay","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Hasanoglu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Kaya","family":"Kalem","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclen","family":"D\u00f6nerta\u015f","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Is\u0131l","family":"Ozkocak Turan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit University of Health Sciences Ankara City Hospital  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesna","family":"Bektas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmet","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology, Ankara City Hospital Ankara Yildirim Beyazit University  Ankara 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