{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:47:52Z","timestamp":1792298872621,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Otomycosis is considered a recurring fungal ear infection. The external auditory canal provides an appropriate and optimal situation for fungal growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aimed to identify the causative agents of otomycosis and determine corresponding antifungal drug susceptibility patterns in north\u2010western Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From October 2020 until November 2021, 200 patients attended an otolaryngology referral centre with otitis externa, and their ear discharge and debris were examined and cultured. The identification of the fungal agents was implemented by polymerase chain reaction\u2010restriction fragment length polymorphism and sequencing. In vitro antifungal susceptibility testing of the isolates was conducted in accordance with the CLSI broth microdilution protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of otomycosis was measured 50.5% (<jats:italic>n<\/jats:italic>\u00a0=\u00a0101\/200). The majority of patients were in their forties (<jats:italic>n<\/jats:italic>\u00a0=\u00a035, 34.6%) and female (<jats:italic>n<\/jats:italic>\u00a0=\u00a057, 56.4%), and the most prevalent symptom was otalgia (56.4%). The most underlying factor was remarked manipulation employing a cotton swab (65.3%). Regarding fungus, <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Nigri<\/jats:italic> (58.57%) was the foremost isolate, followed by <jats:italic>Aspergillus<\/jats:italic> section <jats:italic>Flavi<\/jats:italic> (19.23%) and <jats:italic>Candida parapsilosis<\/jats:italic> (14.96%). The predominance of <jats:italic>Aspergillus<\/jats:italic> isolates had minimal in vitro sensitivity to tioconazole and nystatin. <jats:italic>Candida<\/jats:italic> species represented higher geometric mean minimum inhibitory concentrations (MIC) against nystatin. The MIC of three <jats:italic>Aspergillus<\/jats:italic> species isolates shown above the epidemiologic cut\u2010off values (ECV) against itraconazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Otomycosis incidence surpassed in comparison with the previous study as the most common cause of otitis externa. The MIC distribution of <jats:italic>Aspergillus<\/jats:italic> species isolates against triazole antifungals is close to the defined ECVs and likely outrun it over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13532","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T08:22:31Z","timestamp":1663834951000},"page":"87-97","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Otomycosis: The foremost aetiological agent causing otitis externa and the antifungal susceptibility pattern in North\u2010Western Iran"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-7370","authenticated-orcid":false,"given":"Behrad","family":"Roohi","sequence":"first","affiliation":[{"name":"Communicable Diseases Institute, Invasive Fungi Research Center Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadman","family":"Nemati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Alipour","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Faeli","sequence":"additional","affiliation":[{"name":"Student Research Committee Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabah","family":"Mayahi","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, School of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Haghani","sequence":"additional","affiliation":[{"name":"Communicable Diseases Institute, Invasive Fungi Research Center Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makan","family":"Shalchizadeh","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Darini","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Otorhinolaryngology Research Center, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M. 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