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The present study addresses the global epidemiology, clinical presentation, management and outcome of mucormycosis caused by <jats:italic>Apophysomyces<\/jats:italic> spp. The study included patients diagnosed with <jats:italic>Apophysomyces<\/jats:italic> infection at our hospital between March 2019 and August 2020. In addition, cases published in PubMed and Google Scholar from inception to July 2022 were systematically searched and analysed. Only proven and probable cases that meet the eligibility criteria were included. The Indian cases were compared with those from other countries, and the results were analysed by descriptive statistics. In total, six cases of mucormycosis due to <jats:italic>Apophysomyces<\/jats:italic> spp. were diagnosed at our hospital, with additional 250 cases identified through literature search. The main underlying diseases were diabetes mellitus (24%), malignancy (3.2%) and chronic kidney disease (2.8%). The major predisposing factor was trauma (55.6%). Necrotizing fasciitis was the most common (63.2%) clinical presentation. Healthcare\u2010associated mucormycosis accounted for 10.4% of the cases. Globally, <jats:italic>A.\u00a0elegans<\/jats:italic> was the most common species (48.8%), whereas <jats:italic>A.\u00a0variabilis<\/jats:italic> was predominant (86.2%) in India. Surgery was performed in 83.5% of patients. Among those treated with antifungal agents, 98% received amphotericin B and 8.1% received posaconazole. Inappropriate antifungal usage was observed in 12.7%. The overall mortality was 42.3%. A combined medical and surgical management was associated with higher survival. Our study highlights the knowledge gap among physicians regarding this infection. A timely diagnosis and aggressive management can improve the outcomes in such cases.<\/jats:p>","DOI":"10.1111\/myc.13538","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T15:48:32Z","timestamp":1665676112000},"page":"181-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mucormycosis caused by <i>Apophysomyces<\/i> species: An experience from a tertiary care hospital in Western India and\u00a0systematic review of global cases"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4444-4274","authenticated-orcid":false,"given":"Arghadip","family":"Samaddar","sequence":"first","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Twishi","family":"Shrimali","sequence":"additional","affiliation":[{"name":"Department of 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