{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:41Z","timestamp":1787015861437,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T00:00:00Z","timestamp":1666656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic cavitary pulmonary aspergillosis (CCPA) is the most common form of chronic pulmonary aspergillosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We hypothesise that by observing serial clinical and CT findings of CCPA patients with antifungal therapy, factors helping predict responses to antifungal therapy could be withdrawn.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 31 patients with CCPA who received antifungal therapy for greater than six months and who had serial CT studies were included. Clinical finding analyses were performed at initial and last follow\u2010up CT acquisition dates. Clinical characteristics and CT features were compared between clinically improving or stable and deteriorating groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With antifungal therapy, neutrophil\u2010to\u2010lymphocyte ratio (2.66 vs. 5.12,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.038) and serum albumin (4.40 vs. 3.85\u2009g\/dl,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.013) and CRP (1.10 vs. 42.80\u2009mg\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.007) were different between two groups. With antifungal therapy, meaningful CT change, regardless of clinical response grouping, was decrease in cavity wall thickness (from 13.70\u2009mm to 8.28\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u2009.001). But baseline (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.668) and follow\u2010up (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.278) cavity wall thickness was not different between two groups. In univariate analysis, initial maximum diameter of cavity (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.028; HR [0.983], 95% CI [0.967\u20130.998]) and concurrent NTM infection (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u2009.030; HR [0.20], 95% CI [0.05\u20130.86]) were related factors for poor clinical response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>With antifungal therapy, cavities demonstrate wall thinning. Of all clinical and radiological findings and their changes, initial large cavity size and concurrent presence of NTM infection are related factors to poor response to antifungal therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.13539","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T09:28:38Z","timestamp":1665998918000},"page":"106-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic cavitary pulmonary aspergillosis: Serial clinical and\n                    <scp>CT<\/scp>\n                    findings correlated with antifungal treatment and patient response"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-1360","authenticated-orcid":false,"given":"Yoojin","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Radiology, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-4221","authenticated-orcid":false,"given":"Seong Mi","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-0195","authenticated-orcid":false,"given":"Beomsu","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4468-9589","authenticated-orcid":false,"given":"Nak Gyeong","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Support, Samsung Changwon Hospital Sungkyunkwan University School of Medicine  Changwon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-2671","authenticated-orcid":false,"given":"Junho","family":"An","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-3328","authenticated-orcid":false,"given":"Yu Mi","family":"Wi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases of Internal Medicine, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-5728","authenticated-orcid":false,"given":"Kyung Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Samsung ChangWon Hospital Sungkyunkwan University School of Medicine  ChangWon Gyeongsangnam\u2010Do South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy070"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.174.3.1740795"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.2.541"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.640"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02008-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/657306"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.6.1321"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2462070712"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.40.1238"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12124"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.07.030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.2.341"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812553"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00057-3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02950-2021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx390"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13539","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T07:39:15Z","timestamp":1692517155000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,25]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/myc.13539"],"URL":"https:\/\/doi.org\/10.1111\/myc.13539","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,25]]},"assertion":[{"value":"2022-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}