{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T13:03:38Z","timestamp":1752671018606,"version":"3.40.5"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic> species are opportunistic human pathogens that remarkably cause fungal infections ranging from superficial to fatal invasive disseminated infections. <jats:italic>Fusarium<\/jats:italic> species are notoriously resistant to the majority of antifungal agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Therefore, detailed studies regarding in vitro susceptibility are required and may lead to a better prognosis of severe infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 25 antifungal drugs in vitro against 282 clinical and environmental <jats:italic>Fusarium<\/jats:italic> isolates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic> species demonstrated high MICs\/MECs values to the most commonly used antifungal drugs in clinical practice. The geometric mean (GM) MICs for luliconazole (0.004\u2009\u03bcg\/ml) and lanoconazole (0.012\u2009\u03bcg\/ml) were the lowest, followed by efinaconazole (0.98\u2009\u03bcg\/ml) and amphotericin B (1.04\u2009\u03bcg\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Efinaconazole, a novel triazole, may be a promising candidate for the treatment of superficial <jats:italic>Fusarium<\/jats:italic> infections. Furthermore, the development of systemic formulations of these drugs as well as further in vitro and in vivo investigations could aid in the treatment of systemic fusariosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13550","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:44:34Z","timestamp":1669794274000},"page":"258-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["In vitro antifungal susceptibility profile of Iranian <i>Fusarium<\/i> isolates: Emphasising on the potent inhibitory effect of efinaconazole compared to other drugs"],"prefix":"10.1111","volume":"66","author":[{"given":"Mohsen","family":"Nosratabadi","sequence":"first","affiliation":[{"name":"Department of Medical Mycology, School of Medicine Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Invasive Fungi Research Center Communicable Diseases Institute, Mazandaran University of Medical 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Al Hatmi","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Center of Expertise in Mycology Radboud University Medical Center\/Canisius Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-8414","authenticated-orcid":false,"given":"Hamid","family":"Badali","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology &amp; Immunology, South Texas Center for Emerging Infectious Diseases The University of Texas at San Antonio  Texas San Antonio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-2849","authenticated-orcid":false,"given":"Mahdi","family":"Abastabar","sequence":"additional","affiliation":[{"name":"Department of Medical Mycology, School of Medicine Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Invasive Fungi Research Center Communicable Diseases Institute, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","unstructured":"Vorob'evaI ToropovaE Editors.Fungi ecological niches of the genusFusariumlink. 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