{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:15:40Z","timestamp":1793643340563,"version":"4.5.1"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Itraconazole in varying doses and duration is being frequently used for the management of dermatophytosis. There is a scarcity of studies on the bioavailability of various itraconazole brands available in the market.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objectives<\/jats:title>\n The aim of this study was to determine the plasma concentration of itraconazole of various brands and its correlation with clinical efficacy in chronic dermatophytosis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n One hundred patients with chronic dermatophytosis with age >18\u2009years were studied at the outpatient clinic of our tertiary care hospital. Plasma itraconazole level was estimated on Week 2 and Week 4 after randomly dividing the patients into Groups A, B and C who received cap itraconazole 100\u2009mg twice a day of innovator, multinational and local generic brands, respectively, for 4\u2009weeks. Both efficacy (cure, partial cure or no cure), safety and recurrence were compared between the three groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n At 4\u2009weeks, number of patients classified as \u2018cured\u2019 were 10\/26 (38.4%) in Group A, 5\/22 in Group B (22.7%) and 3\/21 (14.2%) in Group C (\n p<\/jats:italic>\n \u00a0=\u00a0.002). Mycological cure rates at Week 4 in Groups A, B and C were 21 (80.8%), 17 (81.0%) and 5 (26.3%), respectively (\n p<\/jats:italic>\n \u00a0=\u00a0.006). Plasma levels of itraconazole were comparable between the three groups at Week 2 and Week 4. No statistically significant correlation was found between itraconazole levels and treatment response in any of the groups at 4\u2009weeks. Incidence of adverse effects and recurrence rates was also similar among the three groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Cure rates for chronic dermatophytosis were poor with all three itraconazole brands at 4\u2009weeks of treatment. Higher cure rates were obtained with innovator drug as compared to multinational and local generic brands at 4\u2009weeks. Plasma levels of the three drugs were however similar, indicating that factors other than serum bioavailability are at play in determining response of chronic dermatophyte infections to oral itraconazole.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.13551","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T02:57:17Z","timestamp":1669949837000},"page":"281-288","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of plasma levels of itraconazole with treatment response at 4\u2009weeks in chronic dermatophytosis: Results of a randomised controlled trial"],"prefix":"10.1111","volume":"66","author":[{"given":"Hitesh","family":"Bhalavi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipika","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-2330","authenticated-orcid":false,"given":"Hitaishi","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research Chandigarh 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Dermatology, Venereology and Leprology Post Graduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01606.x"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"22","article-title":"Dermatological disease pattern In an urban institution of Kolkata","volume":"50","author":"Das A","year":"2005","journal-title":"Indian J 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