{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:46:17Z","timestamp":1747187177890,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI20C0073"],"award-info":[{"award-number":["HI20C0073"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Organising pneumonia (OP) is reported in patients with haematologic malignancy suspected of having invasive mould disease, yet little is known about this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate molecular evidence of invasive mould pneumonia in paraffin\u2010embedded lung tissues from histologically diagnosed OP patients with suspected invasive mould pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Patients with haematologic malignancy suspected to have invasive pulmonary mould disease who underwent lung biopsy at a tertiary hospital, Seoul, South Korea, between 2008 and 2020, were retrospectively reviewed. To find molecular evidence of fungal infection, PCR assay was used to detect <jats:italic>Aspergillus<\/jats:italic>\u2010 and <jats:italic>Mucorales<\/jats:italic>\u2010specific DNA within OP lung tissue sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010seven patients with suspected invasive mould pneumonia underwent lung biopsy and 15 (32%) were histologically diagnosed as OP without any evidence of fungal hyphae. Of these 15 patients, 3 (20%) received allogenic haematopoietic stem cell transplantation prior to developing OP. Before biopsy, 2 and 13 patients had probably and possible invasive mould disease, respectively. The median antifungal treatment length was 81 [8\u2013114]\u00a0days, and the median steroid treatment dosage was 0.35\u2009mg\/kg\/day for 36\u2009days (methylprednisolone equivalent doses), respectively. After biopsy, three patients with possible invasive mould infection revealed probable invasive pulmonary aspergillosis. From the 15 paraffin\u2010embedded lung tissues, 6 (40%) exhibited positive PCR assay results for detecting <jats:italic>Aspergillus<\/jats:italic>\u2010 and <jats:italic>Mucorales<\/jats:italic>\u2010specific DNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than one third of OP cases in patients with suspected invasive mould pneumonia exhibited molecular evidence of invasive mould infection by fungus\u2010specific PCR in lung tissues, likely associated with concurrent or prior fungal infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13552","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T02:30:42Z","timestamp":1670553042000},"page":"289-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between organising pneumonia and invasive mould disease in patients with haematologic malignancy"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6274-1790","authenticated-orcid":false,"given":"Moonsuk","family":"Bae","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases Department of Internal Medicine Pusan National University Yangsan Hospital  Yangsan Republic of Korea"},{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Seon","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4333-3270","authenticated-orcid":false,"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Oh","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang\u2010Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-8253","authenticated-orcid":false,"given":"Sung\u2010Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216715"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-014-0692-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00328-14"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01185-16"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10168"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01427.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S337321"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2012.08.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.135"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.170"},{"key":"e_1_2_8_13_1","article-title":"Cryptococcosis as a cause of organizing pneumonia","volume":"27","author":"Chikumoto A","year":"2019","journal-title":"Respir Med Case Rep"},{"issue":"12","key":"e_1_2_8_14_1","first-page":"8637","article-title":"Cryptogenic organizing pneumonia associated with invasive pulmonary aspergillosis: a case report and review of the literature","volume":"7","author":"Xie S","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.07.004"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2018.02.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.03.162"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2014.12.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12994"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13319"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/512812"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.4.318"},{"issue":"1","key":"e_1_2_8_25_1","first-page":"511","article-title":"Clinicopathological findings of focal organizing pneumonia: a retrospective study of 37 cases","volume":"8","author":"Huo Z","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00053-10"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325157"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2001.1269"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.035"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.07016"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0883"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180237"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.2005821"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T13:04:30Z","timestamp":1692277470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,18]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/myc.13552"],"URL":"https:\/\/doi.org\/10.1111\/myc.13552","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"type":"print","value":"0933-7407"},{"type":"electronic","value":"1439-0507"}],"subject":[],"published":{"date-parts":[[2022,12,18]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}