{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:11:39Z","timestamp":1781759499169,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candidemia is a life\u2010threatening infection in hospitalied children. This study aimed to evaluate candidemia's demographic and clinical characteristics and identify the risk factors and outcomes of <jats:italic>Candida albicans<\/jats:italic> (CA) and non\u2010<jats:italic>albicans Candida<\/jats:italic> (NAC) spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort was designed to evaluate paediatric patients with candidemia between January 2008 and December 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 342 episodes in 311 patients were evaluated. The median age of the patients was 2.1\u2009years (1\u2009month\u201317\u2009years and 6\u2009months), and 59.6% were male. The prevalence of NAC (67.5%) candidemia was higher than that of CA (32.5%). The most commonly isolated <jats:italic>Candida<\/jats:italic> species was <jats:italic>Candida parapsilosis<\/jats:italic> (43.3%), followed by <jats:italic>C. albicans<\/jats:italic> (32.5%), <jats:italic>Candida glabrata<\/jats:italic> (6.1%) and <jats:italic>Candida tropicalis<\/jats:italic> (5.0%). The length of hospital stay prior to the positive culture and the total length of hospital stay were longer in the NAC group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006). The neutrophil count was lower in the NAC group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007). In the multivariate analysis, total parenteral nutrition, antifungal prophylaxis and a history of coagulase\u2010negative staphylococci (CoNS) culture positivity in the past month were risk factors for developing candidemia due to NAC (<jats:italic>p<\/jats:italic> values were .003, .003 and .045). <jats:italic>C. albicans<\/jats:italic> and C. <jats:italic>parapsilosis<\/jats:italic> fluconazole resistance were 9.5% and 46.6%, respectively. The rates of amphotericin B resistance were 1.1% and 7.6% in <jats:italic>C. albicans<\/jats:italic> and <jats:italic>C. parapsilosis,<\/jats:italic> respectively. Mortality (14\u2010day and 30\u2010day) rates did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A history of CoNS culture positivity in the past month, total parenteral nutrition, and antifungal prophylaxis increases the risk of NAC candidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13564","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T10:38:21Z","timestamp":1672828701000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of candidemia in children at a university hospital: A retrospective cohort"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9725-7501","authenticated-orcid":false,"given":"Gizem","family":"Guner\u00a0Ozenen","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9189-8220","authenticated-orcid":false,"given":"Zumrut","family":"Sahbudak\u00a0Bal","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-3544","authenticated-orcid":false,"given":"Gulhadiye","family":"Avcu","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-2534","authenticated-orcid":false,"given":"Pinar","family":"Ozkaya\u00a0Yazici","sequence":"additional","affiliation":[{"name":"Division of Intensive Care Unit, Department of Pediatrics Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-6256","authenticated-orcid":false,"given":"Miray","family":"Karakoyun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-5031","authenticated-orcid":false,"given":"Dilek Yesim","family":"Metin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-2715","authenticated-orcid":false,"given":"Suleyha","family":"Hilmioglu\u00a0Polat","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Medical School of Ege University  Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S274872"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002530"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vhri.2019.07.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.11.009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piy009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2018.05.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12288"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz005"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11060771"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13296"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002207"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.587278"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa419"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.676177"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/380796"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/596757"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0223"},{"key":"e_1_2_9_21_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Third Informational Supplement. 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