{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:14:59Z","timestamp":1770063299239,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal diseases (IFD) are life\u2010threatening and demand timely and appropriate treatment. Research showed that isavuconazole treatment positively affects clinical outcome and length of hospital stay (LOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to assess the hospital costs of patients diagnosed with IFD and treated with isavuconazole using real\u2010world data from a German cancer centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Data and LOS collected from Jan\u20102016 to Jun\u20102021 at Department I of Internal Medicine, University Hospital Cologne were retrieved. Case\u2010related resources consumed during the hospital stay across isavuconazole routes of administration (oral, parenteral, and mixed administration) were identified, quantified, valued and compared via a cost analysis that adopted the healthcare payer perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 101 cases with isavuconazole treatment were identified (oral:<jats:italic>n<\/jats:italic>\u00a0=\u00a022, 21.8%; parenteral:<jats:italic>n<\/jats:italic>\u00a0=\u00a059, 58.4%; mixed:<jats:italic>n<\/jats:italic>\u00a0=\u00a020, 19.8%). Median total LOS was greater in the mixed group (46.5\u2009days;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). Median ICU LOS and ventilation duration were both longest in the parenteral\u2010only group (16\u2009days,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008; 224\u00a0h,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003). Invasive aspergillosis was the most frequent isavuconazole indication (<jats:italic>n<\/jats:italic>\u00a0=\u00a086, 85.2%). Average hospital costs were highest in the mixed group (\u20ac 101,226). The median overall costs of cases treated with isavuconazole was \u20ac 52,050.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treating IFD is resource intensive, often requires intensive care and implies high rates of in\u2010hospital mortality. Our study emphasises the high hospital treatment costs and thus the need for reimbursement systems to enable live\u2010saving costly treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13567","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T05:20:05Z","timestamp":1674278405000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Health economic analysis of patients treated with isavuconazole in a German comprehensive cancer centre"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-690X","authenticated-orcid":false,"given":"Julia","family":"Jeck","sequence":"first","affiliation":[{"name":"Department I of Internal Medicine University of Cologne, Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"VITIS Healthcare Group Cologne 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Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"VITIS Healthcare Group Cologne Germany"},{"name":"University of Cologne, Faculty of Medicine, and University Hospital Cologne, Centre for Integrated Oncology (CIO ABCD) Cologne Germany"},{"name":"National Network Genomic Medicine Lung Cancer, University Hospital Cologne Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Franz","sequence":"additional","affiliation":[{"name":"Department I of Internal Medicine University of Cologne, Faculty of Medicine, and University Hospital Cologne Cologne Germany"},{"name":"VITIS Healthcare Group Cologne Germany"},{"name":"University of Cologne, Faculty of Medicine, and University Hospital Cologne, Centre for Integrated Oncology (CIO ABCD) Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver 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