{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:51:03Z","timestamp":1776207063822,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies evaluating outcomes of COVID\u201019 patients with candidemia are limited and have only evaluated a single timepoint during the pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the prevalence and outcomes associated with candidemia in patients based on severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) status and through the various pandemic waves (1 March 2020\u20135 March 2022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Multicentre, retrospective cohort analysis of data from 248 US medical facilities using the BD Insights Research Database (Becton, Dickinson and Company, Franklin Lakes, New Jersey, USA). Eligible patients were adults aged \u226518\u2009years who were hospitalised for &gt;1 day, had a SARS\u2010CoV\u20102 test and a positive blood culture for <jats:italic>Candida<\/jats:italic> spp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study time frame, there were 2,402,879 hospital admissions; 234,903 (9.7%) and 2,167,976 (90.3%) patients were SARS\u2010CoV\u20102 positive and negative, respectively. A significantly higher rate of candidemia\/1000 admissions was observed in SARS\u2010CoV\u20102\u2010positive patients compared to SARS\u2010CoV\u20102\u2010negative patients (3.18 vs. 0.99; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The highest candidemia rate for SARS\u2010CoV\u20102\u2010positive patients was observed during the Alpha SARS\u2010CoV\u20102 wave (June 2020\u2013August 2020) with the lowest candidemia rate during the Omicron wave. Hospital mortality was significantly higher in SARS\u2010CoV\u20102\u2010positive patients compared to SARS\u2010CoV\u20102\u2010negative patients with candidemia (59.6% vs. 30.8%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). When evaluating the mortality rate through the various pandemic waves, the rate for the overall population did not change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicates high morbidity and mortality for hospitalised patients with COVID\u201019 and candidemia which was consistent throughout the pandemic. Patients with COVID\u201019 are at an increased risk for candidemia; importantly, the magnitude of which may differ based on the circulating variant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13573","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T05:04:48Z","timestamp":1675659888000},"page":"483-487","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Morbidity and mortality of hospitalised patients with candidemia during the various severe acute respiratory syndrome coronavirus 2 pandemic waves: A multicentre evaluation of 248 <scp>US<\/scp> hospitals"],"prefix":"10.1111","volume":"66","author":[{"given":"Karri A.","family":"Bauer","sequence":"first","affiliation":[{"name":"Merck &amp; Co., Inc.  Rahway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalvin","family":"Yu","sequence":"additional","affiliation":[{"name":"Becton, Dickinson and Company  Franklin Lakes New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela A.","family":"Moise","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  Rahway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Finelli","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  Rahway New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChinEn","family":"Ai","sequence":"additional","affiliation":[{"name":"Becton, Dickinson and Company  Franklin Lakes New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Watts","sequence":"additional","affiliation":[{"name":"Becton, Dickinson and Company  Franklin Lakes New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Ye","sequence":"additional","affiliation":[{"name":"Becton, Dickinson and Company  Franklin Lakes New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[{"name":"Becton, Dickinson and Company  Franklin Lakes New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy776"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.26"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13431"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myab071"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac078"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab562"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.13573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T17:26:56Z","timestamp":1692725216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/myc.13573"],"URL":"https:\/\/doi.org\/10.1111\/myc.13573","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"2022-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}