{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:08:20Z","timestamp":1781932100399,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["202004A17"],"award-info":[{"award-number":["202004A17"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To summarise 71 cases of cutaneous sporotrichosis in Zhejiang over the past 9\u2009years and analyse clinical and epidemiological characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of patients with cutaneous sporotrichosis attending the Department of Dermatology of the Hangzhou Third People's Hospital between 2013 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The male\u2010to\u2010female ratio was 1.15:1 among the 71 patients, with a mean age of 55.90\u2009years (\u00b12.02) and an age range of 3 to 94\u2009years. The disease duration was unknown for 17 patients. The intermediate course for the remaining 54 patients lasted 11.90\u2009months, ranging from 1 to 120\u2009months. Thirty\u2010four patients were involved in mixed occupations, 28 were farmers, 4 were housewives, 3 were manufacturing workers, and 2 were carpenters; 23.95% of cases had a history of trauma. The most common clinical manifestation was fixed cutaneous (69.01%), followed by lymphocutaneous (29.58%) and disseminated cutaneous (1.41%). There were 72 affected sites; the upper limbs (69.44%) were affected the most, followed by the face (16.67%) and lower limbs (12.50%). Forty\u2010nine patients showed open lesions (69.01%), 15 showed mixed lesions (21.13%), and seven showed closed lesions (9.86%). Seventy\u2010one patients were confirmed by biopsied tissue or tissue fluid culture. Forty\u2010four patients underwent direct microscopy; of these, 18 (40.91%) were positive and 26 were negative. Molecular analysis confirmed that all fungal strains were <jats:italic>Sporothrix globosa<\/jats:italic>. Fifty\u2010nine patients underwent histopathological examination, of whom 18 (18.64%) were positive for periodic acid\u2010Schiff (PAS) staining. Eighteen patients were lost to follow\u2010up; the remaining patients were cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consistent with the epidemiological situation of sporotrichosis in other areas of China, <jats:italic>S. globosa<\/jats:italic> is the primary pathogen in the Zhejiang province. The primary clinical form of sporotrichosis is fixed cutaneous. Susceptible subjects are mainly middle\u2010aged and elderly rural populations, and males are affected more than females. Patients with cutaneous sporotrichosis do not commonly have a history of obvious trauma. Direct microscopy is important for the diagnosis of sporotrichosis, and itraconazole is a safe and effective treatment option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13588","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T08:40:51Z","timestamp":1681116051000},"page":"621-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Retrospective analysis of 71 patients with cutaneous sporotrichosis"],"prefix":"10.1111","volume":"66","author":[{"given":"Huijun","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine  Hangzhou 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