{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:02:26Z","timestamp":1791403346050,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic>, a common fungus, emerges as a pathogen in severely immunocompromised patients. We present a series of patients who developed invasive fusariosis (IF) during admission to an acute leukaemia ward: an outbreak of 12 cases in June and July 2018, followed by four sporadic cases until 2021. No case was reported earlier. All patients were clustered in the same location with indoor air and water installations found to be contaminated with <jats:italic>Fusarium<\/jats:italic> spp. thus a nosocomial outbreak was assumed. Following the water installation replacement, the number of <jats:italic>Fusarium<\/jats:italic> cases dramatically dropped to one or two isolated instances per year in the same location. All 16 patients had acute leukaemia and developed IF during severe neutropenia following induction therapy. IF diagnosis was based on positive blood cultures (14 patients) and\/or on tissue biopsies (3 patients). The median time from admission to the IF onset was 20\u2009days, and from the first day of severe neutropenia (\u2264500\/mm3) was 11.5\u2009days. All patients were febrile, eight had moderate\u2010to\u2010severe myalgias, eight had respiratory involvements: lung lesions and\/or sinusitis and seven had characteristic skin lesions. Follow\u2010up: 12 out of 16 (75%) were alive on Day 90; nine out of 15 (60%) were alive on Month 6. All with intractable neutropenia died. In severely neutropenic febrile patients, the triad of respiratory involvement\/skin lesions\/severe myalgia may suggest <jats:italic>Fusarium<\/jats:italic> aetiology. The ability to recover from neutropenia is critical to surmount IF. The indoor environment in immunocompromised dedicated settings must be constantly controlled.<\/jats:p>","DOI":"10.1111\/myc.13596","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T08:51:18Z","timestamp":1683017478000},"page":"705-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Invasive fusariosis in acute leukaemia patients\u2014An outbreak in the haematology ward"],"prefix":"10.1111","volume":"66","author":[{"given":"Andreea\u2010Lacramioara","family":"Mohorea\u2010Neata","sequence":"first","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Camelia","family":"Ghita","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-3752","authenticated-orcid":false,"given":"Ruxandra","family":"Moroti","sequence":"additional","affiliation":[{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy  Bucharest Romania"},{"name":"National Institute for Infectious Diseases \u2018Matei Bals\u2019  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Ghiaur","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia","family":"Tatic","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"},{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Camelia","family":"Stancioaica","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Bardas","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"},{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Al\u2010Hatmi","sequence":"additional","affiliation":[{"name":"Natural &amp; Medical Sciences Research Center University of Nizwa  Nizwa Oman"},{"name":"Centre of Expertise in Mycology Radboud University Medical Centre\/Canisius Wilhelmina Hospital  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-6079","authenticated-orcid":false,"given":"Daniel","family":"Coriu","sequence":"additional","affiliation":[{"name":"Fundeni Clinical Institute  Bucharest Romania"},{"name":"\u2018Carol Davila\u2019 University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005464"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/324501"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00275514.2021.1905497"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.09.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-49"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7100815"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40588-014-0003-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1924-7"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.999"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-017-0247-3"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6640-7_16"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.08.013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3278"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/342328"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12465"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12595"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.017"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.05.019"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa516"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30784-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12409"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.13596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T20:24:03Z","timestamp":1692563043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.13596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/myc.13596"],"URL":"https:\/\/doi.org\/10.1111\/myc.13596","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"2023-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}