{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:54:58Z","timestamp":1792036498610,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Candida auris<\/jats:italic> has become a worrisome multi\u2010drug resistant healthcare\u2010associated pathogen due to its capacity to colonise patients and surfaces and to cause outbreaks of invasive infections in critically ill patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluated the outbreak in our setting in a 4\u2010year period, reporting the risk factors for developing candidemia in previously colonised patients, the therapeutic measures for candidemia and the outcome of candidemia and colonisation cases among all <jats:italic>C. auris<\/jats:italic> isolates and their susceptibility to antifungals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were retrospectively collected from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain) from September 2017 to September 2021. A retrospective case\u2013control study was designed to identify risk factors for developing <jats:italic>C. auris<\/jats:italic> candidemia in previously colonised patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>C. auris<\/jats:italic> affected 550 patients, of which 210 (38.2%) had some clinical sample positive. Isolates were uniformly resistant to fluconazole, 20 isolates were resistant to echinocandins (2.8%) and four isolates were resistant to ampfotericin B (0.6%). There were 86 candidemia cases. APACHE II, digestive disease and catheter isolate were proven to be independent risk factors for developing candidemia in previously colonised patients. Thirty\u2010day mortality rate for <jats:italic>C. auris<\/jats:italic> candidemia cases was 32.6%, while for colonisation cases was 33.7%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Candidemia was one of the most frequent and severe infections caused by <jats:italic>C. auris<\/jats:italic>. The risk factors identified in this study should help to detect patients who are at more risk of developing candidemia, as long as an adequate surveillance of <jats:italic>C. auris<\/jats:italic> colonisation is performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/myc.13626","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T12:07:01Z","timestamp":1688472421000},"page":"882-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["<i>Candida auris<\/i> from colonisation to candidemia: A four\u2010year study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-9068","authenticated-orcid":false,"given":"Juan Vicente","family":"Mulet\u00a0Bayona","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Tormo\u00a0Palop","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Salvador\u00a0Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Remedio","family":"Guna\u00a0Serrano","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Gimeno\u00a0Cardona","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology Consorcio Hospital General Universitario de Valencia  Valencia Spain"},{"name":"Department of Microbiology and Ecology University of Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008921"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.46.2200846"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-023-00451-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12781"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9090558"},{"key":"e_1_2_8_8_1","first-page":"12","article-title":"Retrospective analysis of the clinical characteristics of Candida auris infection worldwide from 2009 to 2020","volume":"12","author":"Hu S","year":"2021","journal-title":"Front Microbiol"},{"issue":"4","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.578","article-title":"Candida auris: a systematic review and meta\u2010analysis of current updates on an emerging multidrug\u2010resistant pathogen","volume":"7","author":"Osei SJ","year":"2018","journal-title":"Microbiology"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00910-19"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02396-16"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00921-17"},{"key":"e_1_2_8_14_1","first-page":"10","article-title":"European Centre for Disease Prevention and Control. 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